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DL-苏-1-苯基-2-棕榈酰氨基-3-吗啉代-1-丙醇

DL-苏-1-苯基-2-棕榈酰氨基-3-吗啉代-1-丙醇结构式
DL-苏-1-苯基-2-棕榈酰氨基-3-吗啉代-1-丙醇结构式
品牌特惠专场
常用名 DL-苏-1-苯基-2-棕榈酰氨基-3-吗啉代-1-丙醇 英文名 D,L-threo-PPMP
CAS号 149022-18-4 分子量 511.18000
密度 1.005g/cm3 沸点 642.8ºC at 760mmHg
分子式 C29H51ClN2O3 熔点 N/A
MSDS 中文版 美版 闪点 342.6ºC

Effect of chum salmon egg lectin on tight junctions in Caco-2 cell monolayers.

Molecules 20 , 8094-106, (2015)

The effect of a chum salmon egg lectin (CSL3) on tight junction (TJ) of Caco-2 cell monolayers was investigated. The lectin opened TJ as indicated by the decrease of the transepithelial electrical resistance (TER) value and the increase of the permeation of l...

Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule.

PLoS ONE 8(12) , e84191, (2013)

It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung met...

Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.

PLoS ONE 8(5) , e63527, (2013)

Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to e...

Improved inhibitors of glucosylceramide synthase.

J. Biochem. 111 , 191, (1992)

An inhibitor of glucosylceramide (GlcCer) synthase, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their glucosphingolipids. This inhibitor has proved useful for the elucidation of the many functions of...

Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells.

Br. J. Cancer 102 , 383-91, (2010)

A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the membrane glycolipid globotriasosylceramide (Gb3), a molecule associated with drug resistan...