DL-苄基丁二酸
DL-苄基丁二酸结构式
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常用名 | DL-苄基丁二酸 | 英文名 | 2-Benzylsuccinic acid |
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| CAS号 | 884-33-3 | 分子量 | 208.211 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 331.4±22.0 °C at 760 mmHg | |
| 分子式 | C11H12O4 | 熔点 | 161-163°C | |
| MSDS | 中文版 美版 | 闪点 | 168.4±18.8 °C |
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Regulation of cytoplasmic tubulin carboxypeptidase activity in vitro by cations and sulfhydryl-modifying compounds.
J. Cell. Biochem. 60(3) , 424-36, (1996) alpha-tubulin subunits within microtubules (MTs) can be post-translationally detyrosinated by a tubulin-specific carboxypeptidase (TCP) activity to form biochemically distinct MTs. Attempts to characterize and purify TCP have suffered from the inability to de... |
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Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.
PLoS ONE 6(4) , e19270, (2011) Nerve injury leads to sensitization mechanisms in the peripheral and central nervous system which involve transcriptional and post-transcriptional modifications in sensory nerves. To assess protein regulations in the spinal cord after injury of the sciatic ne... |
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The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.
EMBO J. 16(23) , 6906-13, (1997) The three-dimensional structure of human procarboxypeptidase A2 has been determined using X-ray crystallography at 1.8 A resolution. This is the first detailed structural report of a human pancreatic carboxypeptidase and of its zymogen. Human procarboxypeptid... |
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Bacterial chemotactic oligopeptides and the intestinal mucosal barrier.
Gastroenterology 97(1) , 61-7, (1989) Intestinal absorption and enterohepatic circulation of N-formyl-methionyl-leucyl-125I-tyrosine, a bioactive synthetic analog of the bacterial chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine has been investigated in the rat. In ileum and proximal a... |
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[Design, synthesis and hypoglycemic activity of alpha-benzylsuccinic acid derivatives].
Yao Xue Xue Bao 44(5) , 491-5, (2009) Based on the SAR of glinide agents, mitiglinide has been modified to study the SAR of glinides. a-Benzylsuccinic acid derivatives which were designed and synthesized in order to find some more hypoglycemic active agents and further investigate the SAR of this... |
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History of heart failure.
Congest. Heart Fail. 15(1) , 49, (2009)
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Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.
J. Am. Chem. Soc. 124(40) , 11852-3, (2002) Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and select... |
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Metabolic by-products of anaerobic toluene degradation by sulfate-reducing enrichment cultures.
Appl. Environ. Microbiol. 58(9) , 3192-5, (1992) Two dead-end metabolites of anaerobic toluene transformation, benzylsuccinic acid and benzylfumaric acid, accumulated in sulfate-reducing enrichment cultures that were fed toluene as the sole carbon source. Stable isotope-labeled toluene and gas chromatograph... |
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Development and design of specific inhibitors of angiotensin-converting enzyme.
Am. J. Cardiol. 49(6) , 1390-4, (1982) Captopril is a remarkably effective new antihypertensive drug designed and developed as a potent and specific inhibitor of angiotensin-converting enzyme, a zinc metallopeptidase that participates in the synthesis of a hypertensive peptide, angiotensin II, and... |
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Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor L-benzylsuccinate at 2.0 A resolution.
J. Mol. Biol. 223(2) , 573-8, (1992) The X-ray crystal structure of the carboxypeptidase A-L-benzylsuccinate complex has been refined at 2.0 A resolution to a final R-factor of 0.166. One molecule of the inhibitor binds to the enzyme active site. The terminal carboxylate forms a salt link with t... |