吡咯他尼
吡咯他尼结构式
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常用名 | 吡咯他尼 | 英文名 | Piretanide |
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| CAS号 | 55837-27-9 | 分子量 | 362.40000 | |
| 密度 | 1.415 g/cm3 | 沸点 | 597.7ºC at 760 mmHg | |
| 分子式 | C17H18N2O5S | 熔点 | 225-227°C (lit.) | |
| MSDS | N/A | 闪点 | 315.3ºC |
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Role of EDHF in the vasodilatory effect of loop diuretics in guinea-pig mesenteric resistance arteries.
Br. J. Pharmacol. 131(6) , 1211-9, (2000) 1. Relaxing effect of loop diuretics, piretanide and furosemide in comparison with acetylcholine (ACh) was investigated in guinea-pig isolated mesenteric resistance arteries. 2. Concentration-response curves to ACh (0.001 - 10 microM) and diuretics (0.0001 - ... |
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Modulation of chloride, potassium and bicarbonate transport by muscarinic receptors in a human adenocarcinoma cell line.
Br. J. Pharmacol. 126(1) , 269-79, (1999) 1. Short-circuit current (I(SC)) responses to carbachol (CCh) were investigated in Colony 1 epithelia, a subpopulation of the HCA-7 adenocarcinoma cell line. In Krebs-Henseleit (KH) buffer, CCh responses consisted of three I(SC) components: an unusual rapid d... |
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Fc epsilon RI-mediated chloride uptake by rat mast cells: modulation by chloride transport inhibitors in relation to histamine secretion.
Br. J. Pharmacol. 122(6) , 1188-94, (1997) 1. We have examined the role of extracellular chloride in the mast cell secretion process. The immunologically-directed ligand, antibody to IgE (anti-IgE) required extracellular chloride ions for optimum secretion from rat peritoneal mast cells. In contrast, ... |
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Usefulness of piretanide plus ramipril for systemic hypertension: a multicenter trial.
Am. J. Cardiol. 72(9) , 666-71, (1993) To test the dose responses of piretanide, ramipril, and their combination in patients with essential hypertension, a prospective, randomized, double-blind, placebo-controlled trial was conducted in 480 patients. Twelve separate groups were studied: placebo, p... |
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Increased (Na+K+Cl) cotransport in rat arterial smooth muscle in deoxycorticosterone (DOCA)/salt-induced hypertension.
J. Vasc. Res. 36(6) , 492-501, (1999) The inhibition by loop diuretics of K efflux (tracer (86)Rb) from the rat femoral arterial smooth muscle was measured in normotension and in DOCA-salt hypertension. The sensitivity sequence (bumetanide > piretanide > furosemide) was the characteristic pharmac... |
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Stability-indicating methods for the determination of piretanide in presence of the alkaline induced degradates.
J. Pharm. Biomed. Anal. 39(5) , 871-6, (2005) Stability-indicating high performance liquid chromatography (HPLC), thin-layer chromatography (TLC) and first-derivative of ratio spectra (1DD) methods are developed for the determination of piretanide in presence of its alkaline induced degradates. HPLC meth... |
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Pharmacokinetics and pharmacodynamics of ramipril and piretanide administered alone and in combination.
Eur. J. Clin. Pharmacol. 46(6) , 545-50, (1994) The pharmacokinetics and pharmacodynamics of single oral doses of 5 mg ramipril and 6 mg piretanide administered separately and in combination were determined in a single blind, randomised, 3-period cross-over study in 24 healthy male volunteers. The peak pla... |
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Piretanide: a loop-active diuretic. Pharmacology, therapeutic efficacy and adverse effects.
Pharmacotherapy 4(4) , 170-80, (1984) Piretanide is a high-ceiling, loop-active diuretic that has been developed for treatment of congestive heart failure, hypertension and edematous states caused by renal and hepatic diseases. Piretanide is structurally related to furosemide and bumetanide; when... |
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Effect of Na/K/2Cl transporter inhibition with piretanide on postischemic kidney function.
Transplant. Proc. 28(1) , 83-4, (1996)
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[Profile of the action of diuretics. Piretanide in comparison with thiazides and anti-kaliuretic drugs].
Internist (Berl.) 33 Suppl 1 , S16-22, (1992)
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