氯噻酮
氯噻酮结构式
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常用名 | 氯噻酮 | 英文名 | Chlorthalidone |
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| CAS号 | 77-36-1 | 分子量 | 338.766 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C14H11ClN2O4S | 熔点 | 265-267ºC (dec.) | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Which diuretic is the preferred agent for treating essential hypertension: hydrochlorothiazide or chlorthalidone?
Curr. Cardiol. Rep. 14(6) , 673-7, (2012) Since their introduction over 50 years ago thiazide and thiazide-like diuretics have been a mainstay in the treatment of hypertension. Yet despite outcome evidence with chlorthalidone, the preponderance of usage has been with hydrochlorothiazide-either as mon... |
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Comparing clinical effectiveness and drug toxicity with hydrochlorothiazide and chlorthalidone using two potency ratios in a managed care population.
J. Clin. Hypertens. (Greenwich.) 17(2) , 134-40, (2015) This study compared the clinical effectiveness and drug toxicity of chlorthalidone and hydrochlorothiazide. Electronic health records and claims data were used to identify patients initially prescribed chlorthalidone or hydrochlorothiazide. A total of 214 pat... |
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Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study.
Ann. Intern. Med. 158(6) , 447-55, (2013) Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension.To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults.Propensity score-matched observational cohort... |
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Clinical inquiry: How do hydrochlorothiazide and chlorthalidone compare for treating hypertension?
J. Fam. Pract. 63(4) , 227-8, (2014)
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Chlorthalidone compared with hydrochlorothiazide in reducing cardiovascular events: systematic review and network meta-analyses.
Hypertension 59 , 1110-1117, (2012) Hydrochlorothiazide (HCTZ) is widely used for hypertension, and prescriptions for HCTZ outnumber those for chlorthalidone (CTDN) by >20-fold in 2 recent surveys. Some have recently expressed a preference for CTDN. However, head-to-head trials testing the effe... |
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Hydrochlorothiazide vs. chlorthalidone as the optimal diuretic for the management of hypertension.
Curr. Pharm. Des. 19(21) , 3766-72, (2013) Even though hydrochlorothiazide (HCTZ) and chlorthalidone are frequently considered interchangeable antihypertensive agents, they appear to differ both in their blood pressure lowering efficacy and in their effects on the lipid profile and on serum potassium,... |
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Is chlorthalidone better than hydrochlorothiazide in reducing cardiovascular events in hypertensives?
Curr. Opin. Cardiol. 28(4) , 426-32, (2013) Hydrochlorthiazide (HCTZ) is the tenth most commonly prescribed drug in recent data. Although no head-to-head trials compare HCTZ with the uncommonly prescribed chlorthalidone (CTDN) in reducing cardiovascular events (CVEs), numerous other data are available.... |
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Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome.
J. Pharmacol. Exp. Ther. , (2014) Experiments determined whether the combination of endothelin A (ETA) receptor antagonist [ABT-627, atrasentan; (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid] and a thiazide diuretic (chlor... |
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Validated stability-indicating methods for the simultaneous determination of amiloride hydrochloride, atenolol, and chlorthalidone using HPTLC and HPLC with photodiode array detector.
J. AOAC Int. 96(2) , 313-23, (2013) Two stability-indicating chromatographic methods are described for simultaneous determination of amiloride hydrochloride (AMI), atenolol (ATE), and chlorthalidone (CHL) in combined dosage forms. The first method was based on HPTLC separation of the three drug... |
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[Importance of the continuity of anti-hypertension treatment in prevention of ischemic cardiovascular diseases: preliminary note. Controlled study of hypertensive patients treated with amiloride associated with hydrochlorothiazide and chlorthalidone].
Minerva Med. 69(31) , 2115-23, (1978)
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