4-Desacetylvinblastine
4-Desacetylvinblastine结构式
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常用名 | 4-Desacetylvinblastine | 英文名 | 4-Desacetylvinblastine |
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| CAS号 | 3352-69-0 | 分子量 | 768.93700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C44H56N4O8 | 熔点 | 189-191℃ | |
| MSDS | N/A | 闪点 | N/A |
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Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography.
Cancer Chemother. Pharmacol. 32(4) , 286-92, (1993) We have developed and validated a selective analytical procedure, based on ion-exchange normal-phase liquid chromatography with fluorescence detection and liquid-liquid extraction, for the analysis of vinblastine (VBL) in biological matrices. The assay is sui... |
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Disposition of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB (LY256787) and free 4-desacetylvinblastine in tumor-bearing nude mice.
J. Pharmacol. Exp. Ther. 241(2) , 695-703, (1987) The monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB (LY256787), and free 4-desacetylvinblastine (DAVLB) were administered i.v. to male athymic nude mice bearing P3/UCLA human lung adenocarcinoma tumors. Although the plasma pharmacokinetics were simi... |
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Quantitation of human anti-mouse antibody in serum by flow cytometry.
Cytometry 13(3) , 275-81, (1992) Clinical investigations utilizing murine monoclonal antibodies require techniques for the detection of the human anti-mouse antibody (HAMA) response in patient serum. We report here a flow cytometric assay for the quantitation of HAMA. Commercially available ... |
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High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolite 4-O-deacetylvinblastine-3-oic acid in biological fluids.
J. Chromatogr. A. 553(1-2) , 47-53, (1991) Procedures for the determination of vinblastine (VBL), 4-O-deacetylvinblastine (DVBL) and 4-O-deacetylvinblastine-3-oic acid (DVBLA) in biological samples using high-performance liquid chromatography (HPLC) combined with selective sample clean-up are presente... |
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Modification of Catharanthus roseus alkaloids: a lactone derived from 17-deacetylvinblastine.
Planta Med. 55(4) , 364-6, (1989) A spirolactone with anti-tumor activity is formed during the reaction of paraformaldehyde with 17-deacetylvinblastine. The compound was identified by NMR techniques. The chemotherapeutic activity was assessed. |