3β-羟基-Δ5-胆烯酸
3β-羟基-Δ5-胆烯酸结构式
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常用名 | 3β-羟基-Δ5-胆烯酸 | 英文名 | 3b-Hydroxy-5-cholenoic acid |
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| CAS号 | 5255-17-4 | 分子量 | 374.55700 | |
| 密度 | 1.11 g/cm3 | 沸点 | 522.8ºC at 760 mmHg | |
| 分子式 | C24H38O3 | 熔点 | 232ºC | |
| MSDS | 美版 | 闪点 | 284.1ºC |
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Hepatic bile salt sulfotransferases in the rat: sulfation of 3 beta-hydroxy-5-cholenoate during development.
J. Pediatr. Gastroenterol. Nutr. 12(2) , 260-8, (1991) Bile salt sulfotransferase (BSS) activity for the fetal bile acid, 3 beta-hydroxy-5-cholenoate, was first detected in the fetus at 18-19 days of gestation and was twofold greater than for glycolithocholate. The near-term (20-21 days of gestation) and newborn ... |
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Determination of 3 beta-hydroxy-5-cholen-24-oic acid and its sulfate in human serum by gas chromatography-mass spectrometry.
Steroids 44(1) , 47-55, (1984) The glycine conjugate of 3 beta-hydroxy-5-cholen-24-oic acid and its sulfate labeled with deuterium at the C-2, -4, and -23 positions were synthesized. A highly sensitive and specific quantitative assay of the bile acid has been developed by selected ion moni... |
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Unusual serum bile acid pattern in children with the syndrome of hepatic ductular hypoplasia.
Clin. Chim. Acta 145(3) , 289-96, (1985) Fasting bile acids in serum of eight children with the syndrome of hepatic ductular hypoplasia were analyzed by gas chromatography. The children did not receive any kind of treatment during the month before the analysis. Serum concentrations of total bile aci... |
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Purification and properties of a novel sulfatase from Pseudomonas testosteroni that hydrolyzed 3 beta-hydroxy-5-cholenoic acid 3-sulfate.
Biosci. Biotechnol. Biochem. 62(9) , 1739-44, (1998) A novel sulfatase hydrolyzing the sulfate ester bond in 3 beta-hydroxy-5-cholenoic acid 3-sulfate (delta 5-3 beta-sulfate) was purified from Pseudomonas testosteroni ATCC 11996 as the second bile acid sulfatase. The molecular weight was 95,000 and the molecul... |
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Preparation and antigenic property of methyl 3 beta-hydroxy-19-oxo-5-cholen-24-oate 19-(O-carboxymethyl) oxime-bovine serum albumin conjugate.
Steroids 41(2) , 155-64, (1983) The preparation and antigenic property of 3 beta-hydroxy-5-cholen-24-oic acid-bovine serum albumin (BSA) conjugate in which the hapten is linked to the carrier protein through an (O-carboxymethyl) oxime bridge at the C-19 position on the steroid nucleus is de... |
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Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons.
Biochem. J. 322 ( Pt 1) , 175-84, (1997) The metabolism of 27-, 25- and 24-hydroxycholesterol in cultures of rat astrocytes, Schwann cells and neurons was studied. 27- and 25-Hydroxycholesterol, but not 24-hydroxycholesterol, underwent 7 alpha-hydroxylation with subsequent oxidation to 7 alpha-hydro... |
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7 alpha-hydroxylation of 26-hydroxycholesterol, 3 beta-hydroxy-5-cholestenoic acid and 3 beta-hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes.
FEBS Lett. 296(1) , 73-6, (1992) Pig liver microsomes were found to catalyze the 7 alpha-hydroxylation of several potential bile acid precursors besides cholesterol. 26-Hydroxycholesterol, 3 beta-hydroxy-5-cholestenoic acid and 3 beta-hydroxy-5-cholenoic acid were all efficiently converted i... |
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Urinary monohydroxy bile acids in young infants with obstructive jaundice.
Acta Paediatr. Scand. 71(1) , 91-5, (1982) Using an aluminum oxide column, we fractionated and quantitatively determined urinary monohydroxy bile acids in young infants. For comparison purposes, monohydroxy bile acids were also measured in urine from older children and adults with obstructive jaundice... |
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Clinical evaluation of serum 3 beta-hydroxy-5-cholenoic acid in hepatobiliary diseases.
Gastroenterol. Jpn. 21(6) , 608-16, (1986) Serum 3 beta-hydroxy-5-cholenoic acid (3 beta-OH-delta 5) was analyzed in 100 cases (90 patients with hepatobiliary diseases, 10 normal subjects) and its clinical significance investigated. The measurement of 3 beta-OH-delta 5 was performed by high performanc... |
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Bile acid synthesis: down-regulation by monohydroxy bile acids.
FASEB J. 2(2) , 152-6, (1988) The regulation of bile acid synthesis was studied in rabbits after interruption of the enterohepatic circulation by choledochoureteral anastomosis. Total daily bile acid output was 772 +/- 130 (SD) mumol/24 h, of which greater than 95% was glycocholic acid. A... |