2-(呋喃-2-基)-7-(3-(4-甲氧基苯基)丙基)-7H-吡唑啉[4,3-e][1,2,4]三唑[1,5-c]嘧啶-5-胺
![2-(呋喃-2-基)-7-(3-(4-甲氧基苯基)丙基)-7H-吡唑啉[4,3-e][1,2,4]三唑[1,5-c]嘧啶-5-胺结构式](https://image.chemsrc.com/caspic/127/316173-57-6.png)
2-(呋喃-2-基)-7-(3-(4-甲氧基苯基)丙基)-7H-吡唑啉[4,3-e][1,2,4]三唑[1,5-c]嘧啶-5-胺结构式
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常用名 | 2-(呋喃-2-基)-7-(3-(4-甲氧基苯基)丙基)-7H-吡唑啉[4,3-e][1,2,4]三唑[1,5-c]嘧啶-5-胺 | 英文名 | SCH 442416 |
|---|---|---|---|---|
| CAS号 | 316173-57-6 | 分子量 | 389.411 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C20H19N7O2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles.
J. Physiol. 592(Pt 12) , 2575-90, (2014) Adenosine (ADO) is an endogenous vasodilatory purine widely recognized to be a significant contributor to functional hyperaemia. Despite this, many aspects of the mechanisms by which ADO induces dilation in small resistance arterioles are not established, or ... |
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Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.
Am. J. Physiol. Heart Circ. Physiol. 299(4) , H1262-4, (2010) Pre- and postconditioning depend on the activation of adenosine receptors (ARs) at the end of the index ischemia. The aim of this study was to determine which receptor subtypes must be activated. In situ mouse hearts underwent 30 min of regional ischemia, fol... |
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Pulsed electromagnetic fields increased the anti-inflammatory effect of A₂A and A₃ adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts.
PLoS ONE 8(5) , e65561, (2013) Adenosine receptors (ARs) have an important role in the regulation of inflammation and their activation is involved in the inhibition of pro-inflammatory cytokine release. The effects of pulsed electromagnetic fields (PEMFs) on inflammation have been reported... |
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Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model.
J. Pharm. Sci. 103 , 329-332, (2007) In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A(2A) antagonist SCH-58261, bu... |
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Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats.
Psychopharmacol. Ser. 231(16) , 3179-88, (2014) Adenosine receptor stimulation and blockade have been shown to modulate a variety of cocaine-related behaviors.These studies identify the direct effects of adenosine receptor stimulation on cocaine seeking during extinction training and the persistent effects... |