硫酸魁蛤素
硫酸魁蛤素结构式
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常用名 | 硫酸魁蛤素 | 英文名 | Arcaine sulfate |
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| CAS号 | 14923-17-2 | 分子量 | 270.31 | |
| 密度 | 1.37g/cm3 | 沸点 | 408.9ºC at 760mmHg | |
| 分子式 | C6H18N6O4S | 熔点 | 291°C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 201.1ºC |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice.
Bull. Exp. Biol. Med. 146(1) , 18-21, (2008) Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the development of seizures induced by systemic treatment with nicotine in the toxic dose. The Me3N+ group with st... |
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Spermidine decreases Na+,K+-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats
Eur. J. Pharmacol. 684(1-3) , 79-86, (2012) Spermidine is an endogenous polyamine with a polycationic structure present in the central nervous system of mammals. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-d-aspartate receptor (NMDA receptor), which has been... |
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Systemic administration of polyaminergic agents modulate fear conditioning in rats.
Psychopharmacology 192(4) , 457-64, (2007) The polyamines putrescine, spermine, and spermidine are a group of aliphatic amines that physiologically modulate the N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor implicated in memory formation.Given the potential application of these drugs in t... |
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Polyamines reduces lipid peroxidation induced by different pro-oxidant agents.
Brain Res. 1008(2) , 245-51, (2004) Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we i... |
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Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats.
Eur. J. Pharmacol. 444(1-2) , 83-96, (2002) The aim of this study was to evaluate the effect of multiple acamprosate (500.0 mg/kg, p.o.) administration on short-term memory, using the social recognition test in rats. Ifenprodil (1.0 mg/kg, i.p.), arcaine (5.0 mg/kg, i.p.) and spermidine (20.0 mg/kg, i.... |
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Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats.
Psychopharmacology 215(3) , 483-91, (2011) Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state... |
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The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement.
Behav. Brain Res. 187(1) , 200-4, (2008) Achievements made over the last years have highlighted the important role of creatine in health and disease. However, studies of its effect on cognition function have been limited. In the present study, we investigated the effect of creatine on early consolid... |
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Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor.
Brain Res. 954(2) , 300-7, (2002) Human immunodeficiency virus type-I (HIV-1) infection is often associated with neuronal loss in cortical and subcortical regions that may manifest as motor dysfunction and dementia. The function of the HIV-1 transcription protein Tat and subsequent activation... |
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The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site.
Brain Res. 995(1) , 39-45, (2004) Human immunodeficiency virus type-1 (HIV-1) infection is commonly associated with neuronal loss, as well as, cognitive and motor deficits collectively termed HIV-1-associated dementia (HAD). Function of the HIV-1 transcription factor Tat, activation of N-meth... |