Spantide I
Spantide I结构式
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常用名 | Spantide I | 英文名 | Spantide I TFA |
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| CAS号 | 91224-37-2 | 分子量 | 1497.79000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C75H108N20O13 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
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Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety.
Braz. J. Med. Biol. Res. 45(4) , 349-56, (2012) Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulati... |
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Solution conformation of Substance P antagonists-[D-Arg1, D-Trp7,9, Leu11]-SP, [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP and [D-Pro2, D-Trp7,9]-SP by CD, NMR and MD simulations.
Peptides 26 , 875-885, (2005) Substance P (SP) is an important neuropeptide involved in pain transmission and induction of inflammation. Its antagonists are being extensively investigated for their non-narcotic analgesic and anti-inflammatory activity. With a view towards better understan... |
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Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors.
Neuropeptides 41(1) , 25-31, (2007) Substance P (SP) is a widely distributed neuropeptide that works as a neurotransmitter and neuromodulator. Recently, SP receptors, particularly neurokinin-1 receptors (NK(1)-Rs) that have a high affinity for SP, have been observed not only in neuron and immun... |
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Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions.
Invest. Ophthalmol. Vis. Sci. 52(12) , 8604-13, (2011) To determine whether substance P (SP) in herpes simplex virus-1 (HSV-1) infected cornea regulates the severity of herpetic stromal keratitis (HSK) lesions in a mouse model.C57BL/6 mice were infected ocularly with HSV-1 (RE). The corneas with HSK lesions, on D... |
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Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.
Mol. Pain 3 , 30, (2007) Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Inflammatory neuropeptides are sugges... |
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Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells.
Int. J. Biochem. Cell Biol. 44(12) , 2342-8, (2012) Skin pigmentation plays a number of valuable roles and its regulation is a complex process that is controlled by different factors. Substance P (SP) regulates many biological functions, including neurogenic inflammation, pain, and stress. However, to date, th... |
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Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
Neuroscience 201 , 134-45, (2012) The dorsal periaqueductal gray (dPAG) is the main output structure for the defensive response to proximal aversive stimulation. Panic-like responses, such as freezing and escape behaviors, often result when this structure is electrically stimulated. Freezing ... |
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Elevated glucose and fatty acid levels impair substance P-induced dermal microvascular endothelial cell migration and proliferation in an agarose gel model system.
Shock 32(5) , 491-7, (2009) Substance P (SP), a sensory nerve derived neuropeptide, has been implicated in wound repair. Our hypothesis was that oxidative effects of elevated glucose and fatty acid levels as seen with diabetes mellitus inhibit SP-mediated endothelial cell directional mi... |
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Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice.
J. Pharmacol. Sci. 100(4) , 297-302, (2006) The purpose of the present study was to investigate the involvement of chemical mediators, other than histamine, in the scratching behavior induced by H(3) antagonists. Scratching behavior was induced by the histamine H(3) antagonists iodophenpropit and clobe... |
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Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation.
Peptides 31(9) , 1767-71, (2010) Endokinins, encoded by the human preprotachykinin C (PPT-C)/TAC4 gene, are peptides that consist of endokinin A (EKA), B (EKB), C (EKC) and D (EKD) and belong to the tachykinin family. Intrathecal injection of EKC/D (using the common carboxyl-terminal duodeca... |