2-氨基异丁酸
2-氨基异丁酸结构式
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常用名 | 2-氨基异丁酸 | 英文名 | 2-Aminoisobutyric acid |
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| CAS号 | 62-57-7 | 分子量 | 103.120 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 204.4±23.0 °C at 760 mmHg | |
| 分子式 | C4H9NO2 | 熔点 | ≥300 °C | |
| MSDS | 中文版 美版 | 闪点 | 77.4±22.6 °C |
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.
Nature 457(7231) , 910-4, (2009) Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an... |
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Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling
J. Chromatogr. A. 1218(23) , 3689-94, (2011) We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of ion-pairing (IP) reversed-phase (RP) LC as the first dimensio... |
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Isotope-labeled differential profiling of metabolites using N-benzoyloxysuccinimide derivatization coupled to liquid chromatography/high-resolution tandem mass spectrometry.
Rapid Commun. Mass Spectrom. 29 , 1632-40, (2015) An isotopic labeling strategy based on derivatizing amine-containing metabolites has been developed using light ((12) C6 ) and heavy ((13) C6 ) N-benzoyloxysuccinimide reagents for semi-targeted metabolomic applications.Differentially labeled samples were com... |
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Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been... |
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Specificity of the volume-activated amino acid efflux pathway in cultured human breast cancer cells.
Gen. Physiol. Biophys. 30(1) , 45-51, (2011) It has been shown that cell swelling stimulates the efflux of taurine from MCF-7 and MDA-MB-231 cells via a pathway which has channel-like properties. The purpose of this study was to examine the specificity of the volume-activated taurine efflux pathway in b... |
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Light-modulated seminal wavy roots in rice mediated by nitric oxide-dependent signaling.
Protoplasma 252 , 1291-304, (2015) Rice (Oryza sativa L.) seminal roots from germinated seeds help establish seedlings, but the seminal root growth and morphology are sensitive to environmental factors. Our previous research showed that several indica-type rice varieties such as Taichung nativ... |
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Antimicrobial lipopeptaibol trichogin GA IV: role of the three Aib residues on conformation and bioactivity.
Amino Acids 43(4) , 1761-77, (2012) The lipopeptaibol trichogin GA IV is a natural, non-ribosomally synthesized, antimicrobial peptide remarkably resistant to the action of hydrolytic enzymes. This feature may be connected to the multiple presence in its sequence of the non-coded residue α-amin... |
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Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid.
J. Pept. Sci. 18(7) , 466-75, (2012) A pair of L-leucine (L-Leu) and D-leucine (D-Leu) was incorporated into a-aminoisobutyric acid (Aib) peptide segments. Thedominant conformations of four hexapeptides, Boc-L-Leu-Aib-Aib-Aib-Aib-L-Leu-OMe (1a), Boc-D-Leu-Aib-Aib-Aib-Aib-L-Leu-OMe(1b), Boc-Aib-A... |
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Evaluation of functional groups on amino acids in cyclic tetrapeptides in histone deacetylase inhibition.
Amino Acids 42(6) , 2103-10, (2012) The naturally occurring cyclic tetrapeptide, chlamydocin, originally isolated from fungus Diheterospora chlamydosphoria, consists of α-aminoisobutyric acid, L-phenylalanine, D-proline and an unusual amino acid (S)-2-amino-8-((S)-oxiran-2-yl)-8-oxooctanoic aci... |
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Replacement of Ala by Aib improves structuration and biological stability in thymine-based alpha-nucleopeptides.
Org. Biomol. Chem. 8(6) , 1315-21, (2010) Three thymine-based nucleo-heptapeptides, each containing two nucleo-amino acids and zero, one or four Aib residues, respectively, have been synthesized. A single Aib residue is enough to promote the adoption of a helical structure in our nucleopeptides and t... |