6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤
6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤结构式
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常用名 | 6-(甲硫基)-9-β-D-呋喃核糖-9H-嘌呤 | 英文名 | Inosine,6-S-methyl-6-thio- |
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| CAS号 | 342-69-8 | 分子量 | 298.32 | |
| 密度 | 1.85g/cm3 | 沸点 | 636.3ºC at 760mmHg | |
| 分子式 | C11H14N4O4S | 熔点 | 166°C | |
| MSDS | 中文版 美版 | 闪点 | 338.6ºC |
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The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease.
Ther. Drug Monit. 33 , 200-208, (2011) There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an incre... |
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Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa.
Biochemistry 51(45) , 9094-103, (2012) Pseudomonas aeruginosa possesses an unusual pathway for 5'-methylthioadenosine (MTA) metabolism involving deamination to 5'-methylthioinosine (MTI) followed by N-ribosyl phosphorolysis to hypoxanthine and 5-methylthio-α-d-ribose 1-phosphate. The specific MTI ... |
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A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.
Scand. J. Gastroenterol. 40(10) , 1205-13, (2005) 6-thioguanine (6-TG) has emerged as a promising therapeutic alternative in patients with Crohn's disease intolerant or resistant to azathioprine (AZA) and/or 6-mercaptopurine (6-MP). The aim of the present study was to evaluate the safety and efficacy of 6-TG... |
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Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner.
J. Gen. Virol. 89 , 1000-1009, (2008) The family Flaviviridae comprises positive-strand RNA viral pathogens of humans and livestock with few treatment options. We have previously shown that azathioprine (AZA) has in vitro activity against bovine viral diarrhea virus (BVDV). While the mechanism of... |
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Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.
Biochemistry 50(7) , 1247-54, (2011) The PA3004 gene of Pseudomonas aeruginosa PAO1 was originally annotated as a 5'-methylthioadenosine phosphorylase (MTAP). However, the PA3004 encoded protein uses 5'-methylthioinosine (MTI) as a preferred substrate and represents the only known example of a s... |
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A thiopurine drug inhibits West Nile virus production in cell culture, but not in mice.
PLoS ONE 6(10) , e26697, (2011) Many viruses within the Flavivirus genus cause significant disease in humans; however, effective antivirals against these viruses are not currently available. We have previously shown that a thiopurine drug, 6-methylmercaptopurine riboside (6MMPr), inhibits r... |
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Methotrexate increases red blood cell concentrations of 6-methylmercaptopurine ribonucleotide in rats in vivo.
Cancer Chemother. Pharmacol. 40(4) , 367-70, (1997) To elucidate the effect of methotrexate (MTX) on 6-mercaptopurine (6-MP) metabolism in rats.Fourteen rats were given 6-MP 20 mg/kg daily for 7 days. Seven of the rats were also given MTX 20 mg/kg on days 5 and 7. Blood samples were obtained from all rats on d... |
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Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside (MMPR), and leucovorin in patients with advanced cancer.
Invest. New Drugs 15(2) , 139-45, (1997) The results of several clinical trials support the hypothesis that biochemical modulation may enhance the antitumor activity of 5-Fluorouracil (5-FU). We have performed a phase I trial using a combination of three different biochemical modulators at the optim... |
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Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers.
Molecules 10(8) , 1015-20, (2005) 6-Methylpurine-beta-D-riboside (beta-D-MPR) has been synthesized by coupling 6-methylpurine and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribose using conditions that produce the beta-D-anomer exclusively. The in vitro antitumor effects of beta-D-MPR and 6-methyl-puri... |
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Evaluation of chemotherapy and radiation enhancement and 31P NMR spectral changes induced by biochemical modulation.
Cancer Invest. 15(2) , 111-20, (1997) The combination of N-(phosphonacetyl)-L-aspartate (PALA), 6-methylmercaptopurine riboside (MMPR), and 6-aminonicotinamide (6AN) has been shown to be an effective antineoplastic regimen and also to enhance the effects of other antineoplastic agents (1-4). To f... |