碱性蓝 7
碱性蓝 7结构式
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常用名 | 碱性蓝 7 | 英文名 | victoria pure blue bo |
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| CAS号 | 2390-60-5 | 分子量 | 514.144 | |
| 密度 | N/A | 沸点 | 612.2ºC at 760mmHg | |
| 分子式 | C33H40ClN3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 324ºC |
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Mitochondrial effects of triarylmethane dyes.
J. Bioenerg. Biomembr. 31 , 581-90, (1999) The mitochondrial effects of submicromolar concentrations of six triarylmethane dyes, with potential applications in antioncotic photodynamic therapy, were studied. All dyes promoted an inhibition of glutamate or succinate-supported respiration in uncoupled m... |
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Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of autologous bone marrow grafts from residual tumor cells.
J. Pharm. Sci. 89(1) , 88-99, (2000) Extensively conjugated cationic molecules with appropriate structural features naturally accumulate into the mitochondria of living cells, a phenomenon typically more prominent in tumor than in normal cells. Because a variety of tumor cells also retain pertin... |
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Reduced cellular glutathione levels do not affect the cytotoxicity or photocytotoxicity of the cationic photosensitiser Victoria Blue BO.
Membr. Cell Biol. 14(3) , 357-66, (2000) Victoria Blue BO (VBBO) is thought to exert its photocytotoxic effects via free radical generation. Glutathione and related enzymes are associated with the protection of normal tissues against free-radical damage and have also been implicated in multiple drug... |
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Electron paramagnetic resonance evidence of the generation of superoxide (O2.-) and hydroxyl (.OH) radicals by irradiation of a new photodynamic therapy photosensitizer, Victoria Blue BO.
J. Photochem. Photobiol. B, Biol. 32(1-2) , 49-58, (1996) Electron paramagnetic resonance (EPR) experiments were performed on Victoria Blue BO, a cationic dye whose photocytotoxicity has been studied against the human leukaemic cell lines K-562 and TF-1. EPR experiments with 2,2,6,6-tetramethyl-4-piperidone and spin... |
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GRP78 induction by calcium ionophore potentiates photodynamic therapy using the mitochondrial targeting dye victoria blue BO.
Photochem. Photobiol. 67(1) , 155-64, (1998) The cationic photosensitizing triaryl methane dye Victoria Blue BO (VBBO) localizes in mitochondria and causes oxidative damage to this organelle during photodynamic therapy (PDT). Oxidative stresses from other photosensitizers induce a variety of stress prot... |
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Comparison of photodynamic targets in a carcinoma cell line and its mitochondrial DNA-deficient derivative.
Photochem. Photobiol. 71(6) , 747-57, (2000) The relative contribution, to cell death, of photodynamic damage to respiratory proteins (known targets of photodynamic therapy with many photosensitizers) and other cellular sites was examined. The models were a human ovarian carcinoma cell line 2008, and it... |
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Metabolic effects of photodynamically induced apoptosis in an erythroleukemic cell line. A (31)P NMR spectroscopic study of Victoria-Blue-BO-sensitized TF-1 cells.
Int. J. Cancer 85(5) , 733-9, (2000) Victoria Blue BO (VB BO) is a new and promising photosensitizer currently being evaluated for photodynamic therapy (PDT). Its photochemical processes are mediated by oxygen radicals, but do not involve singlet oxygen. We used (31)P NMR spectroscopy of VB-BO s... |
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Efficient photodynamic action of Victoria blue BO against the human leukemic cell lines K-562 and TF-1.
Photochem. Photobiol. 58(3) , 356-61, (1993) Photodynamic induced cytotoxicity by Victoria blue BO (VB-BO), merocyanine 540 (MC540), Nile blue A (NB) and 4-tetrasulfonatophenyl-porphyrin (4-TSPP) has been studied on two human leukemic cell lines: K-562 and TF-1. Cells were incubated with dyes and irradi... |
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The photodynamic effect of Victoria blue BO on peripheral blood mononuclear and leukemic cells.
Photochem. Photobiol. 65(5) , 855-61, (1997) The photodynamic effect of Victoria blue BO (VB-BO) and photoirradiation on peripheral blood mononuclear cells was studied. The cells were preincubated with VB-BO followed by photoirradiation and overnight culture. The highest percentage of dead cells (propid... |
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Photodynamic modulation by Victoria Blue BO of phenylephrine-induced calcium oscillations in freshly isolated rat hepatocytes.
Photochem. Photobiol. Sci. 1(12) , 1001-5, (2002) The adrenergic agonist phenylephrine (PE) induced typical [Ca2+]i oscillations in freshly isolated rat hepatocytes, and the photodynamic effect of Victoria Blue BO on induced calcium oscillations was investigated. PE induced calcium oscillations disappeared a... |