(±)-盐酸喹吡罗
(±)-盐酸喹吡罗结构式
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常用名 | (±)-盐酸喹吡罗 | 英文名 | Quinpirole dihydrochloride |
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| CAS号 | 73625-62-4 | 分子量 | 255.78700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C13H22ClN3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
J. Neurosci. 31 , 5512-25, (2011) An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D(2) receptors, which are the main target of antipsychotics, modulate the ... |
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A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
Hum. Mol. Genet. 24(7) , 1929-44, (2015) The essential micronutrient manganese is enriched in brain, especially in the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested that alterations in striatal mang... |
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Biphasic effect of D-2 agonist quinpirole on locomotion and movements.
Eur. J. Pharmacol. 161 , 151-157, (1989) The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the drug had a biphasic effect: th... |
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Compounds selective for dopamine receptor subtypes. Kebabian, et al.
Drug Discov. Today 2 , 333-340, (1997)
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Infusion of quinpirole and muscimol into the ventral tegmental area inhibits fear-potentiated startle: implications for the role of dopamine in fear expression.
Brain Res. 746 , 231-238, (1997) Dopamine (DA) D2 and gamma-aminobutyric acid (GABA)A somatodendritic receptors tonically inhibit mesolimbic projection neurons in the A10 DA cell grouping of the ventral tegmentum. In the present study we determined the contribution of the ventral tegmental a... |
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K-channel blockers attenuate the presynaptic effects of the D2/D3 agonist quinpirole in monkeys.
Pharmacol. Biochem. Behav. 51 , 843-848, (1995) The present study investigated whether potassium channel blockade could modify the behavioral effects of the dopamine D2/D3 receptor agonist quinpirole in squirrel monkeys. The duration of immobility and/or unusual postures indicative of catalepsy-associated ... |