4- 雌-3Alpha,17Β-二醇
4- 雌-3Alpha,17Β-二醇结构式
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常用名 | 4- 雌-3Alpha,17Β-二醇 | 英文名 | estren |
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| CAS号 | 35950-87-9 | 分子量 | 276.41400 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C18H28O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Reversal of bone loss in mice by nongenotropic signaling of sex steroids.
Science 298 , 843-846, (2002) We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone ... |
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The nongenotropic synthetic ligand 4-estren-3alpha17beta-diol is a high-affinity genotropic androgen receptor agonist.
Mol. Pharmacol. 67 , 744-748, (2005) The nongenotropic ligand estren (Science 298:843-846, 2002) was evaluated for its transcriptional activity mediated by the human androgen receptor (AR). Our results show that estren can bind, translocate, transactivate, and regulate two known target genes of ... |
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The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection.
Neurobiol. Dis. 19 , 331-339, (2005) Estrogen has demonstrated neuroprotective properties, which may underlie the observed preventive effect of estrogen-based hormone therapy (HT) against the development of neurodegenerative disorders such as Alzheimer's disease. Deleterious side effects of HT h... |
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Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands.
BMC Immunol. 6 , 16, (2005) Estrogens and androgens have extensive effects on the immune system, for example they suppress both T and B lymphopoiesis in thymus and bone marrow. Submandibular glands are sexually dimorphic in rodents, resulting in larger granular convoluted tubules in mal... |