苄基-2-乙酰胺基-2-脱氧-Α-D-吡喃半乳糖苷
苄基-2-乙酰胺基-2-脱氧-Α-D-吡喃半乳糖苷结构式
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常用名 | 苄基-2-乙酰胺基-2-脱氧-Α-D-吡喃半乳糖苷 | 英文名 | O-glycosylation-IN-1 |
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| CAS号 | 3554-93-6 | 分子量 | 311.33000 | |
| 密度 | 1.34g/cm3 | 沸点 | 594.9ºC at 760mmHg | |
| 分子式 | C15H21NO6 | 熔点 | 201-203°C | |
| MSDS | 美版 | 闪点 | 313.6ºC |
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Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.
Fertil. Steril. 95(2) , 823-5, (2011) The attachment of endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) with and without inhibition of N- and O-linked glycosylation, the viability of EECs and ESCs, and the expression of CD44 surface ... |
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Antiadhesive character of mucin O-glycans at the apical surface of corneal epithelial cells.
Invest. Ophthalmol. Vis. Sci. 49(1) , 197-203, (2008) Prolonged contact of opposite mucosal surfaces, which occurs on the ocular surface, oral cavity, reproductive tract, and gut, requires a specialized apical cell surface that prevents adhesion. The purpose of this study was to evaluate the contribution of muci... |
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Benzyl-N-acetyl-alpha-D-galactosaminide induces a storage disease-like phenotype by perturbing the endocytic pathway.
J. Biol. Chem. 278(14) , 12374-83, (2003) The sugar analog O-benzyl-N-acetyl-alpha-d-galactosaminide (BG) is an inhibitor of glycan chain elongation and inhibits alpha2,3-sialylation in mucus-secreting HT-29 cells. Long-term exposure of these cells to BG is associated with the accumulation of apical ... |
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Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule.
Int. J. Cancer 88(4) , 507-18, (2000) MUC1 mucin expression has been shown to be associated clinicopathologically with metastasis and poor clinical outcome in a variety of tumors. To further investigate this finding experimentally, human pancreatic cancer S2-013 cells overexpressing MUC1 were use... |
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Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains.
J. Biol. Chem. 277(12) , 10683-90, (2002) The apical sorting of human intestinal dipeptidyl peptidase IV (DPPIV) occurs through complex N-linked and O-linked carbohydrates. Inhibition of O-linked glycosylation by benzyl-N-acetyl-alpha-d-galactosaminide affects significantly the sorting behavior of DP... |
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N-Glycans influence the in vitro adhesive and invasive behaviour of three metastatic cell lines.
Tumour Biol. 21(3) , 165-75, (2000) Alterations in cellular glycosylation may play a key role in metastatic behaviour of tumour cells. We studied three metastatic cell lines, LOX (malignant melanoma), FEMX (malignant melanoma) and MA-11 (mammary carcinoma). These cell lines have a very differen... |
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N-acetyllactosamine and the CT carbohydrate antigen mediate agrin-dependent activation of MuSK and acetylcholine receptor clustering in skeletal muscle.
Mol. Cell. Neurosci. 15(4) , 380-97, (2000) Galbeta1,3GalNAc and Galbeta1,4GIcNAc are the subterminal saccharide structures present on the CT carbohydrate antigen GalNAcbeta1,4[NeuAcalpha2,3]-Galbeta1-(3GalNAc or 4GIcNAc)-R, which is localized at the mammalian neuromuscular junction. Here we show that ... |
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Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain.
Br. J. Cancer 97(7) , 910-8, (2007) Mucins are high molecular weight glycoproteins expressed on the apical surface of normal epithelial cells. In cancer disease mucins are overexpressed on the entire cellular surface. Overexpression of MUC1 mucin in pancreatic tumours has been correlated with p... |
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Differential distribution of sialic acid in alpha2,3 and alpha2,6 linkages in the apical membrane of cultured epithelial cells and tissues.
J. Histochem. Cytochem. 49(4) , 501-10, (2001) We used lectin cytochemistry and confocal microscopy to examine the distribution of sialic acid in epithelial cells. Maackia amurensis lectin and Sambuccus nigra agglutinin were used to detect alpha2,3 and alpha2,6 sialic acid, respectively. In Caco-2, HT-29 ... |
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Mucin overexpression limits the effectiveness of 5-FU by reducing intracellular drug uptake and antineoplastic drug effects in pancreatic tumours.
Eur. J. Cancer 45(1) , 164-73, (2009) Current treatments for pancreatic cancer have failed to effectively manage the disease, and hence, more effective treatment approaches are urgently needed. Studies suggest that mucin O-glycosylation limits the cytotoxic effect of fluorouracil (5-FU) against t... |