4,4,4,4',4',4'-六氟-DL-缬氨酸
4,4,4,4',4',4'-六氟-DL-缬氨酸结构式
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常用名 | 4,4,4,4',4',4'-六氟-DL-缬氨酸 | 英文名 | 4,4,4,4',4',4'-Hexafluoro-DL-valine |
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| CAS号 | 16063-80-2 | 分子量 | 225.08900 | |
| 密度 | 1.575 g/cm3 | 沸点 | 165.9ºC at 760 mmHg | |
| 分子式 | C5H5F6NO2 | 熔点 | 204°C (dec.) | |
| MSDS | 美版 | 闪点 | 54.1ºC |
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Synthesis of fluorine-containing peptides. Analogues of angiotensin II containing hexafluorovaline.
J. Med. Chem. 24(9) , 1043-7, (1981) Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hexafluorovaline derivatives showed general resistance toward ... |
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Long-acting angiotensin II inhibitors containing hexafluorovaline in position 8.
J. Med. Chem. 30(6) , 1097-100, (1987) An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-Hfv8]AII. At the nanogram/milliliter dose range, the L conge... |
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