L-APB
L-APB结构式
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常用名 | L-APB | 英文名 | L-AP4 |
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| CAS号 | 23052-81-5 | 分子量 | 183.100 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 491.7±55.0 °C at 760 mmHg | |
| 分子式 | C4H10NO5P | 熔点 | 207-215 °C | |
| MSDS | 中文版 美版 | 闪点 | 251.2±31.5 °C |
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The rat retina has five types of ganglion-cell photoreceptors.
Exp. Eye Res. 130 , 17-28, (2014) Intrinsically photosensitive retinal ganglion cells (ipRGCs) are inner retinal photoreceptors that mediate non-image-forming visual functions, e.g. pupillary constriction, regulation of pineal melatonin release, and circadian photoentrainment. Five types of i... |
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Examination of VLC-PUFA-deficient photoreceptor terminals.
Invest. Ophthalmol. Vis. Sci. 55(7) , 4063-72, (2014) Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very long chain fatty acids (VLC-FAs ≥ C26). Photoreceptors are ... |
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Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.
J. Physiol. 592(Pt 19) , 4201-20, (2014) Adenosine is an established neuromodulator in the mammalian retina, with A1 adenosine receptors being especially prevalent in the innermost ganglion cell layer. Activation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cycl... |
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Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery.
Bioorg. Med. Chem. 16 , 5501-13, (2008) A combination of a literature survey, structure-based virtual screening and synthesis of a small library was performed to identify hits to the potential antimycobacterial drug target, glutamine synthetase. The best inhibitor identified from the literature sur... |
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Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.
Bioorg. Med. Chem. Lett. 16 , 196-9, (2006) Two novel constrained l-AP4 analogues, (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines (7) and (8), were synthesized and evaluated as mGluR ligands. Compound 7 showed to be a group III mGluRs agonist with micromolar activity. |
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Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Bioorg. Med. Chem. 17 , 242-50, (2009) A novel series of bicyclo[1.1.1]pentane-based omega-acidic amino acids, including (2S)- and (2R)-3-(3'-carboxybicyclo[1.1.1]pentyl)alanines (8 and 9), (2S)- and (2R)-2-(3'-carboxymethylbicyclo[1.1.1]pentyl)glycines (10 and 11), and (2S)- and (2R)-3-(3'-phosph... |
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Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Bioorg. Med. Chem. 15 , 3161-70, (2007) Four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine were synthesized by a stereocontrolled synthetic procedure and evaluated as mGluRs ligands. The (2S,1'R,2'S,3'R)-isomer (PPCG-2) showed to be a group III mGluRs selective ligand endowed w... |
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Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
J. Med. Chem. 48 , 2534-47, (2005) The "receiver operating characteristic" (ROC) curve method is a well-recognized metric used as an objective way to evaluate the ability of a given test to discriminate between two populations. This facilitates decision-making in a plethora of fields in which ... |
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NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells.
J. Physiol. 592(Pt 22) , 4877-89, (2014) Postsynaptic AMPA- and NMDA-type glutamate receptors (AMPARs, NMDARs) are commonly expressed at the same synapses. AMPARs are thought to mediate the majority of fast excitatory neurotransmission whereas NMDARs, with their relatively slower kinetics and higher... |
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The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
J. Neurosci. 35 , 13336-50, (2015) Much of the computational power of the retina derives from the activity of amacrine cells, a large and diverse group of GABAergic and glycinergic inhibitory interneurons. Here, we identify an ON-type orientation-selective, wide-field, polyaxonal amacrine cell... |