多 L -精氨酸 盐酸盐
多 L -精氨酸 盐酸盐结构式
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常用名 | 多 L -精氨酸 盐酸盐 | 英文名 | Poly-L-arginine hydrochloride |
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| CAS号 | 26982-20-7 | 分子量 | 210.66200 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C6H15ClN4O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery.
Biomaterials 33(28) , 6793-807, (2012) Due to the absence of safe and effective carriers for in vivo delivery, the applications of small interference RNA (siRNA) in clinic for therapeutic purposes have been limited. In this study, a biodegradable amphiphilic tri-block copolymer (mPEG(2000)-PLA(300... |
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RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells.
PLoS ONE 10 , e0129806, (2015) Interleukin-12 (IL-12) is an important cytokine for the immunomodulatory effects of lactic acid bacteria (LAB). Using murine immune cells, we previously reported that the RNA of Enterococcus faecalis EC-12, a LAB strain exerting probiotic-like beneficial effe... |
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RVG-mediated calpain2 gene silencing in the brain impairs learning and memory.
Neuromolecular Med. 15(1) , 74-81, (2013) In the central nervous system, two calpain isoforms are highly expressed: calpain1 and calpain2. Here, we show for the first time that activation of the calpain isoform, calpain2, is a necessary event in hippocampal synaptic plasticity and in learning and mem... |
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The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.
J. Cell Biol. 205(3) , 301-12, (2014) The etoposide-induced protein Ei24 was initially identified as a p53-responsive, proapoptotic factor, but no clear function has been described. Here, we use a nonbiased proteomics approach to identify members of the importin (IMP) family of nuclear transporte... |
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Controlled enzyme-catalyzed degradation of polymeric capsules templated on CaCO₃: influence of the number of LbL layers, conditions of degradation, and disassembly of multicompartments.
J. Control. Release 162(3) , 599-605, (2012) Enzyme-catalyzed degradation of CaCO₃-templated capsules is presented. We investigate a) biodegradable, b) mixed biodegradable/synthetic, and c) multicompartment polyelectrolyte multilayer capsules with different numbers of polymer layers. Using confocal lase... |
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Combining poly-arginine with the hydrophobic counter-anion 4-(1-pyrenyl)-butyric acid for protein transduction in transdermal delivery
Biomaterials 33(27) , 6468-75, (2012) Topical therapy is the most favored form of treatment for whitening against hyperpigmentation and sunburn because it lends itself to self-administration, patient compliance, and absence of systemic adverse effects. However, transdermal delivery of hydrophilic... |
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A "turn-off" SERS-based detection platform for ultrasensitive detection of thrombin based on enzymatic assays.
Biosens. Bioelectron. 44 , 10-5, (2013) Herein we describe a novel "turn-off" biosensing strategy for thrombin detection based on Surface Enhanced Raman scattering (SERS) and the mediation of spacing between 4-mercaptobenzoic acid (4-MBA) labeled gold nanoparticles (AuNPs). The multiple arginine pe... |
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Enhanced skin permeation using polyarginine modified nanostructured lipid carriers.
J. Control. Release 161(3) , 735-45, (2012) The objective of the present study was to investigate the effect of polyarginine chain length on topical delivery of surface modified NLCs. Design of experiments (DOE) was used to optimize number of arginines required to deliver active drug into deeper skin l... |
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Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy.
Nanoscale 4(22) , 7185-93, (2012) A multifunctional gold (Au) nanorod (NR)-based nanocarrier capable of co-delivering small interfering RNA (siRNA) against achaete-scute complex-like 1 (ASCL1) and an anticancer drug (doxorubicin (DOX)) specifically to neuroendocrine (NE) cancer cells was deve... |
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Grafting of cell-penetrating peptide to receptor-targeted liposomes improves their transfection efficiency and transport across blood-brain barrier model.
J. Pharm. Sci. 101(7) , 2468-78, (2012) We report bifunctional liposomal delivery system, combining transferrin (Tf)-mediated receptor targeting and poly-L-arginine (PR)-facilitated cell penetration, which overcomes the drawback of saturation of delivery. PR was conjugated to the distal end of dist... |