β-Casomorphin (1-5) (bovine)
β-Casomorphin (1-5) (bovine)结构式
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常用名 | β-Casomorphin (1-5) (bovine) | 英文名 | β-Casomorphin (1-5) (bovine) acetate salt |
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| CAS号 | 72122-63-5 | 分子量 | 579.64 | |
| 密度 | 1.362 g/cm3 | 沸点 | 1002.4ºC at 760 mmHg | |
| 分子式 | C30H37N5O7 | 熔点 | 230ºC | |
| MSDS | 美版 | 闪点 | 560ºC |
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Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with mu-opioid receptor-sensitizing properties.
Br. J. Pharmacol. 140(1) , 13-22, (2003) (1) Here, we introduce a beta-casomorphin-5-derived cyclic pentapeptide, cCD-2 (Tyr-cyclo[d-Orn-Tyr(Bzl)-Pro-Gly]), which inhibits the cell growth of a variety of human cancer cell lines. (2) This opioid-derived peptide possesses only low affinity for mu-rece... |
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Metabolism of D-proline beta-casomorphin derivatives in the rat brain.
Biomed. Biochim. Acta 47(9) , 865-9, (1988) The aim of the present study was to evaluate the metabolic breakdown of two biologically active derivatives of beta-casomorphin (beta CM)-i.e. D-proline4-beta CM (D-Pro4-beta CM) and des-tyrosine 1-D-proline4-beta CM (DT-D-Pro4-beta CM)- in the rat brain. Aft... |
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[Synthesis and biological activity of new analogs of beta-casomorphine-5].
Bioorg. Khim. 20(7) , 740-50, (1994) Four new analogues of beta-cazomorphine-5 modified at the C-end with ethylenediamine- and glycine-containing derivatives were synthesized by the standard method of peptide chemistry (mixed anhydrides, carbodiimide, activated esters): H-Tyr-Pro-Phe-Pro-Gly-EtD... |
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Morphiceptin and beta-casomorphin-5 analogues containing a reduced peptide bond: selective mu-receptor agonists and a novel mu antagonist, H-Tyr-Pro psi (CH2-NH)Phe-Pro-Gly-OH.
Biopolymers 32(8) , 957-69, (1992) In order to prevent enzymatic degradation of beta-casomorphin-5 (1) and morphiceptin, reduced peptide bonds were incorporated at the 2-3 and 3-4 bonds, respectively. The analogues were synthesized by a combination of solid phase methodology and reductive alky... |
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Assignment of the 1H-NMR resonances of the four rotamers of beta-casomorphin-5 in DMSO.
Biopolymers 31(12) , 1409-16, (1991) We report the complete assignment of the 1H-nmr spectrum of beta-casomorphin-5 in DMSO-d6 solution. With a combination of one-dimensional, double quantum filtered correlated spectroscopy, homonuclear Hartmann-Hahn, and rotating frame nuclear Overhauser enhanc... |
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Nonopioid effects of beta-casomorphin-5 in guinea pig heart: alterations to the beta-adrenoceptor-G-protein complex and inhibition of myocardial responses to isoproterenol.
Peptides 12(2) , 265-70, (1991) The influence of beta-casomorphin-5 on the beta-adrenoceptor complex in guinea pig heart membranes was studied by means of binding studies, G-protein investigations and isolated heart preparations. In nanomolar concentrations beta-CM-5 induced an increase in ... |
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Phe1-substituted beta-casomorphin-5 analogues with analgesic activity.
Peptides 15(3) , 457-60, (1994) The antinociceptive potency of linear and cyclic beta-casomorphin-5 (CM-5) analogues, modified in position 1 by substitution of the tyrosine (Tyr) by the phenylalanine (Phe) residue, was studied using the vocalization test. With the exception of the linear [P... |
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Effects of beta-casomorphin-5 on passive avoidance response in mice.
Biosci. Biotechnol. Biochem. 67(11) , 2501-4, (2003) The effects of intracerebroventricular (i.c.v.) injection of bovine beta-casomorphin-5 (beta-CM-5: Tyr-Pro-Phe-Pro-Gly), a micro-opioid agonist derived from milk beta-casein, on step-down type passive avoidance tasks were investigated in mice. Intracerebroven... |
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Structure-activity studies of novel casomorphin analogues: binding profiles towards mu 1-, mu 2- and delta -opioid receptors.
Pharmazie 46(5) , 345-8, (1991) The beta -casomorphin-5 sequence was systematically modified by substitution of the naturally occurring amino acids. The derivatives are compared on the basis of their affinities towards mu 1-, mu 2 and delta -opioid binding sites estimated by means of bindin... |
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Effects of beta-casomorphin on 3H-ouabain binding to guinea pig heart membranes.
Pharmazie 41(9) , 670-1, (1986)
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