α-内啡肽
α-内啡肽结构式
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常用名 | α-内啡肽 | 英文名 | α-Endorphin |
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| CAS号 | 59004-96-5 | 分子量 | 1745.95000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C77H120N18O26S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors.
J. Biol. Chem. 282 , 27126-32, (2007) G-protein activation by receptors is generally measured using (35)S-GTPgammaS binding assays in cell membranes and cannot be well assessed in intact cells. We have recently developed a fluorescence resonance energy transfer (FRET)-based approach to monitor G(... |
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gamma endorphin, alpha endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment.
Nature 269(5629) , 619-21, (1977)
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Selective conversion of beta-endorphin into peptides related to gamma- and alpha-endorphin.
Nature 283(5742) , 96-7, (1980) beta-Endorphin (beta-LPH61-91) is a well known endogenous opioid ligand. It and related peptides have recently been implicated in the control of adaptive behaviour. Smaller beta-endorphin fragments appeared to be more active moieties than the parent molecule ... |
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Effects of [Des-Tyr 1]-gamma-endorphin and alpha-endorphin on substantia nigra self-stimulation.
Pharmacol. Biochem. Behav. 10(6) , 899-905, (1979)
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Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.
Proc. Natl. Acad. Sci. U. S. A. 73(11) , 3942-6, (1976) The isolation and primary structure of two peptides with morphinomimetic activity, obtained from an extract of porcine hypothalamus-neurohypophysis, are described. The amino acid sequence of the two peptides, named alpha-endorphin and gamma-endophin, was dete... |
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Analysis of the beta-endorphin structure-related activity on human monocyte chemotaxis: importance of the N- and C-terminal.
Peptides 10 , 565-569, (1989) We evaluated the chemotactic activity of beta-endorphin and beta-endorphin-related peptides on human monocytes. We tested beta-endorphin(1-31) and fragments (1-16), (1-17), (1-27) in which the N-terminal of the opioid is preserved, N-acetyl-beta-endorphin(1-3... |
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B-lipotropin 61-76 and 61-91 fragments act as transglutaminase substrates in vitro.
Neuropeptides 11 , 89, (1988) Both alpha- and beta-endorphin were shown to incorporate radioactive polyamines during incubation in the presence of purified transglutaminase and Ca2+, spermine acting as the best acyl acceptor substrate. The endorphin labelling is dependent on the time of e... |
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Identification of N alpha-acetyl-alpha-endorphin and N alpha-acetyl-gamma-endorphin isolated from the neurointermediate lobe of the rat pituitary gland.
J. Biol. Chem. 260 , 6663-6669, (1985) The peptides that represent the major components with alpha-endorphin- and gamma-endorphin-like immunoreactivity in the rat neurointermediate lobe were purified to homogeneity and chemically characterized. Rat neurointermediate lobes were extracted by boiling... |
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Studies on the structural prerequisites for the activation of the beta-endorphin receptor on the rat vas deferens.
J. Pharmacol. Exp. Ther. 222 , 262-269, (1982) The inhibitory activity of a variety of opioid peptides was tested on the electrically stimulated rat vas deferens. Human beta-endorphin (beta h-EP) was the most potent of the opoioid-like peptides; it produced half-maximal inhibition of the neuromuscular twi... |
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Opioid activities of fragments of beta-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin.
Eur. J. Pharmacol. 58 , 11, (1979) For characterisation in vitro, four parallel assays were used: the guinea-pig ileum and mouse vas deferens as pharmacological models at 36 degrees C and the inhibition of binding of [3H]-naltrexone, [3H]-leucine-enkephalin and [3H]-methione-enkephalin at 0 de... |