四聚甘氨酸
四聚甘氨酸结构式
|
常用名 | 四聚甘氨酸 | 英文名 | H-Gly-Gly-Gly-Gly-OH |
|---|---|---|---|---|
| CAS号 | 637-84-3 | 分子量 | 246.22100 | |
| 密度 | 1.393g/cm3 | 沸点 | 800.9ºC at 760 mmHg | |
| 分子式 | C8H14N4O5 | 熔点 | 300 °C | |
| MSDS | 美版 | 闪点 | 438.2ºC |
|
Clostridium difficile sortase recognizes a (S/P)PXTG sequence motif and can accommodate diaminopimelic acid as a substrate for transpeptidation.
FEBS Lett. 588(23) , 4325-33, (2014) Covalent attachment of surface proteins to the cell wall of Gram-positive bacteria requires a sortase-mediated transpeptidation reaction. In almost all Gram-positive bacteria, the housekeeping sortase, sortase A, recognizes the canonical recognition sequence ... |
|
|
Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: impending synergistic agents.
Bioorg. Med. Chem. Lett. 18 , 5512-7, (2008) Tetrapeptides derived from glycine and beta-alanine were hooked at the C-3beta position of the modified cholic acid to realize novel linear tetrapeptide-linked cholic acid derivatives. All the synthesized compounds were tested against a wide variety of microo... |
|
|
Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding.
J. Med. Chem. 49 , 3636-44, (2006) The human intestinal oligopeptide transporter (PEPT1) facilitates the absorption of dipeptides, tripeptides, and many peptidomimetic drugs. In this study, a large number of peptides were selected to investigate the structural features required for PEPT1 trans... |
|
|
Coordination of (glycyl)(n)glycine (n = 1-3) to Co+ and Co2+.
J. Phys. Chem. A 113(31) , 8883-92, (2009) This paper analyses the interaction of Co+ (d8, 1G, and 3F) and Co2+ (d7, 4F) cations with (glycyl)(n)glycine (n = 1-3) oligomers. The structure, relative energies, and binding energies of the complexes formed have been theoretically determined by means of de... |
|
|
Oxidative DNA damage induced by Cu(II)-oligopeptide complexes and hydrogen peroxide.
Biochem. Mol. Biol. Int. 34(4) , 801-8, (1994) At physiological pH values, Cu(II)-tetraglycine and Cu(II) complexes with peptides containing a histidyl residue at the N-terminal caused DNA strand breakage in the presence of H2O2, whereas Cu(II) complexes with peptides containing histidyl residue in the se... |
|
|
Solid-state IR-LD spectroscopic and theoretical analysis of glycine-containing peptides and their hydrochlorides.
Biopolymers 82(6) , 587-96, (2006) As part of an investigation on the coordination ability of peptides, structural analyses of the solid di-, tri, and tetrapeptides glycyl-glycine (GG), glycyl-glycyl-glycine (GGG), glycyl-glycyl-glycyl-glycine (GGGG), and their protonated hydrochlorides glycyl... |
|
|
The effect of disorder on the chemical reactivity of an organic solid, tetraglycine methyl ester: change of the reaction mechanism.
J. Pharm. Sci. 91(2) , 584-93, (2002) Many drugs undergo chemical changes in the solid state, and understanding chemical reactivity of organic crystals is a critical factor in the drug development process. In this report, the impact of milling on the thermal chemical reactivity of an organic soli... |
|
|
Effect of nickel(II) and tetraglycine on hydroxylation of the guanine moiety in 2'-deoxyguanosine, DNA, and nucleohistone by hydrogen peroxide.
Sci. Total Environ. 148(2-3) , 207-16, (1994) The purpose of this study was to determine whether the Ni(II)-tetraglycine complex system (NiG4) that is known to disproportionate H2O2 at pH > or = 8 can catalyze oxidation of the guanine residues in 2'-deoxyguanosine (dG), calf thymus DNA, and calf thymus n... |
|
|
Copper-induced oligomerization of peptides: a model study.
Eur. J. Mass Spectrom. (Chichester, Eng.) 13(5) , 331-7, (2007) In this work, copper-binding of the tetraglycine peptide (Gly-Gly-Gly-Gly) was studied by electrospray ionization mass spectrometry. Experiments were performed under alkaline conditions, in the presence of ethanolamine (pH 10.95). We observed that the presenc... |
|
|
Chemiluminescent reaction of sulphite auto-oxidation in the presence of Ni(II)/tetraglycine and ruthenium(II)/bipy complexes: mechanistic considerations.
Luminescence 20(6) , 428-34, (2005) The present work is a mechanistic study of the possible analytical chemiluminescent reaction of sulphite oxidation in the presence of dissolved oxygen, Ni(II)/tetraglycine and [RuII(bipy)3]2+ ions. The Ni(III) complex oxidizes SO32- to SO3-, reacts with oxyge... |