PKA Inhibitor (5-24)
PKA Inhibitor (5-24)结构式
|
常用名 | PKA Inhibitor (5-24) | 英文名 | PKI (5-24) |
|---|---|---|---|---|
| CAS号 | 99534-03-9 | 分子量 | 2222.38000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C94H148N32O31 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
|
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.
J. Biol. Chem. 261 , 989, (1986) As an important new reagent for studying the cAMP-dependent protein kinase, a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein. This synthetic peptide inhibits the protein kinase competitivel... |
|
|
Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.
J. Thorac. Cardiovasc. Surg. 285 , 33843-57, (2010) The Group VIA phospholipase A(2) (iPLA(2)β) hydrolyzes glycerophospholipids at the sn-2-position to yield a free fatty acid and a 2-lysophospholipid, and iPLA(2)β has been reported to participate in apoptosis, phospholipid remodeling, insulin secretion, trans... |
|
|
Release of Ca2+ by inositol 1,4,5-trisphosphate in platelet membrane vesicles is not dependent on cyclic AMP-dependent protein kinase.
Biochem. J. 257(3) , 715-21, (1989) In contrast with previous reports, it was found that membrane-protein phosphorylation by the catalytic subunit (CS) of cyclic AMP-dependent protein kinase had no effect on Ca2+ uptake into platelet membrane vesicles or on subsequent Ca2+ release by inositol 1... |
|
|
Luteinizing hormone (LH) acts through PKA and PKC to modulate T-type calcium currents and intracellular calcium transients in mice Leydig cells.
Cell Calcium 49(3) , 191-9, (2011) LH increases the intracellular Ca(2+) concentration ([Ca(2+)](i)) in mice Leydig cells, in a process triggered by calcium influx through T-type Ca(2+) channels. Here we show that LH modulates both T-type Ca(2+) currents and [Ca(2+)](i) transients through the ... |
|
|
Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase.
Cell Regul. 1(13) , 1015-25, (1990) We have shown previously that cytoplasmic extracts from actively dividing lymphoid cells are capable of inducing DNA synthesis in isolated nuclei. One of the factors involved in this activity, ADR, appears to be a greater than 90 kDa heat-labile protease. Cyt... |
|
|
Protein kinase-dependent phosphorylation and cannabinoid receptor modulation of potassium A current (IA) in cultured rat hippocampal neurons.
Pflugers Arch. 439(5) , 541-6, (2000) The potent cannabinoid receptor agonist WIN 55,212-2 produces positive shifts in steady-state inactivation of the potassium A current (IA) in rat hippocampal neurons via an adenosine 3',5'-cyclic monophosphate (cAMP)-, protein kinase A (PKA)-dependent process... |
|
|
Inhibitory effect of TNF-alpha on the intestinal absorption of galactose.
J. Cell. Biochem. 101(1) , 99-111, (2007) Sepsis is a systemic response to infection in which toxins, such as bacterial lipopolysaccharide (LPS), stimulate the production of inflammatory mediators like the cytokine tumor necrosis factor alpha (TNF-alpha). Previous studies from our laboratory have rev... |
|
|
Mechanisms of norepinephrine mediated corticotropin-releasing factor-41 release from cultured fetal hypothalamic cells.
Neuroendocrinology 56(5) , 712-8, (1992) Catecholamines have been shown to activate hypothalamic corticotropin-releasing factor-41 (CRF) synthesis and release. In order to study the mechanisms involved, fetal hypothalamic cells were cultured and CRF release was measured by radioimmunoassay. Norepine... |
|
|
Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin.
Biochim. Biophys. Acta 1355(3) , 331-42, (1997) We examined the effects of platelet activators and inhibitors of platelet function on the voltage-gated delayed rectifier K+ current of human megakaryocytes. We found that both the activators such as thrombin, the thrombin receptor peptide (TRP42-47) and ADP ... |
|
|
5-Hydroxytryptamine stimulates corticosteroid-sensitive CRF release from cultured foetal hypothalamic cells. Role of protein kinases.
Brain Res. 574(1-2) , 266-70, (1992) 5-Hydroxytryptamine (5-HT) has been shown to activate the hypothalamo-pituitary-adrenal axis, possibly by a direct action on hypothalamic CRF synthesis and release. In order to study the mechanisms involved in this effect, foetal hypothalamic cells were cultu... |