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4-氯-N-[2-[[5-(三氟甲基)-2-吡啶基]磺酰基]乙基]-苯甲酰胺

4-氯-N-[2-[[5-(三氟甲基)-2-吡啶基]磺酰基]乙基]-苯甲酰胺结构式
4-氯-N-[2-[[5-(三氟甲基)-2-吡啶基]磺酰基]乙基]-苯甲酰胺结构式
品牌特惠专场
常用名 4-氯-N-[2-[[5-(三氟甲基)-2-吡啶基]磺酰基]乙基]-苯甲酰胺 英文名 GSK3787
CAS号 188591-46-0 分子量 392.781
密度 1.4±0.1 g/cm3 沸点 585.1±50.0 °C at 760 mmHg
分子式 C15H12ClF3N2O3S 熔点 N/A
MSDS 美版 闪点 307.7±30.1 °C

The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.

PLoS Pathog. 10(6) , e1004167, (2014)

Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, ...

Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin.

Toxicol. Appl. Pharmacol. 294 , 32-42, (2016)

One proposed contributing factor to the rise in overweight and obesity is exposure to endocrine disrupting chemicals. Tributyltin chloride (TBT), an organotin, induces adipogenesis in cell culture models and may increases adipose mass in vivo in vertebrate mo...

Telmisartan activates endothelial nitric oxide synthase via Ser1177 phosphorylation in vascular endothelial cells.

PLoS ONE 9(5) , e96948, (2014)

Because endothelial nitric oxide synthase (eNOS) has anti-inflammatory and anti-arteriosclerotic functions, it has been recognized as one of the key molecules essential for the homeostatic control of blood vessels other than relaxation of vascular tone. Here,...

Prostacyclin and PPARα agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms.

PLoS ONE 8 , e69702, (2013)

We hypothesized that prostacyclin (PGI2) protects vascular smooth muscle cell (VSMC) against apoptosis and phenotypic switch through peroxisome proliferator-activated receptor-α (PPARα) activation and 14-3-3 upregulation. Here we showed that transfection of r...