奥沙拉嗪钠
奥沙拉嗪钠结构式
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常用名 | 奥沙拉嗪钠 | 英文名 | Olsalazine (Disodium) |
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| CAS号 | 6054-98-4 | 分子量 | 346.203 | |
| 密度 | N/A | 沸点 | 557.9ºC at 760 mmHg | |
| 分子式 | C14H8N2Na2O6 | 熔点 | 240ºC | |
| MSDS | N/A | 闪点 | 291.2ºC |
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Treatment of ulcerative colitis with oral mesalamine: advances in drug formulation, efficacy expectations and dose response, compliance, and chemoprevention.
Rev. Gastroenterol. Disord. 6(2) , 97-105, (2006) Sulfasalazine, olsalazine, balsalazide, delayed-release mesalamine, controlled-release mesalamine, mesalamine pellets, and Multi-Matrix System mesalamine are effective first-line therapies for the treatment of mildly to moderately active ulcerative colitis an... |
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Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice.
Life Sci. 92(12) , 708-18, (2013) Although acute dextran sodium sulphate (DSS)-induced colitis in mice is frequently used as a preclinical model for testing drugs involved in inflammatory bowel disease (IBD), only limited data is available that compares the efficacy of established drug treatm... |
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Study of the plasma pharmacokinetics and faecal excretion of the prodrug olsalazine and its metabolites after oral administration to horses.
J. Vet. Pharmacol. Ther. 25(2) , 135-43, (2002) Olsalazine sodium (Dipentum*) has been used therapeutically against inflammatory bowel disease in human medicine as an alternative to sulphasalazine over the past 20 years. Bacteria in the colon split this prodrug into two molecules of the locally effective 5... |
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Different therapy for different types of ulcerative colitis in China.
World J. Gastroenterol. 10(10) , 1513-20, (2004) To study the different therapy for different types of ulcerative colitis (UC) in China.Among 102 UC patients, 42 chronic relapse type UC patients were randomly divided into olsalazine sodium treatment group (n=21) and SASP group (n=21). Clinical effects and s... |
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High thiopurine metabolite concentrations associated with lymphopenia in inflammatory bowel disease (IBD) pediatric patients receiving aminosalicylates combined with azathioprine.
Int. J. Clin. Pharmacol. Ther. 48(4) , 275-81, (2010) Aminosalicylates are widely used with azathioprine in the treatment of IBD. The association results in an increase in 6-TGN levels in adults with IBD with a difference in the occurrence of myelotoxic effects. Scarce data are available in pediatric population.... |
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Role of mesalazine in acute and long-term treatment of ulcerative colitis and its complications.
Scand. J. Gastroenterol. Suppl. (236) , 42-7, (2002) Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term mainten... |
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Comparison of the electrochemical properties of some colon-specific prodrugs of mesalazine.
Pharmazie 57(7) , 468-70, (2002) The electrochemical behavior of 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid, 2-hydroxy-5-[(3-sulfophenyl)azo]benzoic acid and 2-hydroxy-5-[(2-sulfophenyl)-azo]benzoic acid was investigated by cyclic voltammetry using a glassy carbon electrode. The influence ... |
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Efficacy and tolerability of olsalazine (dipentum) in the treatment of patients with ulcerative colitis--results of a field study.
Hepatogastroenterology. 53(69) , 317-21, (2006) In the treatment of ulcerative colitis, 5-aminosalicylic acid is the standard therapy for both acute exacerbations of the disease and the maintenance of remission. Clinical studies have shown that olsalazine (Dipentum)--a prodrug converted to two molecules of... |
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Thrombocytopenia associated with 5-aminosalicylate prodrug, olsalazine: is the devil still there?
Int. J. Clin. Pharm. 35(4) , 529-31, (2013) We present a case of a 63-year-old Chinese female who developed severe thrombocytopenia after receiving olsalazine 1.5 g daily for 3 months, and eventually culminated in hospital admission. According to a Medline search, this is the first case report of olsal... |
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Treating TNBS-induced colitis in rats with probiotics.
Turk. J. Gastroenterol. 22(5) , 486-93, (2011) We aimed to investigate the therapeutic effects of Peifeikang, a probiotics compound, on colitis in rats induced by trinitrobenzene sulfonic acid and to elucidate its potential mechanism.We evaluated the therapeutic effects of Peifeikang by analysis of the di... |