(+/-)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯氮杂卓氢溴酸
(+/-)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯氮杂卓氢溴酸结构式
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常用名 | (+/-)-6-氯-7,8-二羟基-3-烯丙基-1-苯基-2,3,4,5-四氢-1H-3-苯氮杂卓氢溴酸 | 英文名 | SKF 82958 |
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| CAS号 | 80751-65-1 | 分子量 | 329.82 | |
| 密度 | 1.234 g/cm3 | 沸点 | 473.7ºC at 760 mmHg | |
| 分子式 | C19H20ClNO2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 240.3ºC |
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FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization.
Mol. Endocrinol. 29(3) , 421-33, (2015) The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role as a transcriptiona... |
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Different contributions of dopamine D1 and D2 receptor activity to alcohol potentiation of brain stimulation reward in C57BL/6J and DBA/2J mice.
J. Pharmacol. Exp. Ther. , (2014) C57BL/6J (C57) and DBA/2J (DBA) mice respond differently to drugs that affect dopamine systems, including alcohol. The current study compared effects of D1 and D2 receptor agonists and antagonists, and the interaction between D1/D2 antagonists and alcohol, on... |
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PKA and ERK1/2 are involved in dopamine D₁ receptor-induced heterologous desensitization of the δ opioid receptor.
Life Sci. 92(23) , 1101-9, (2013) Chronic administration of cocaine attenuates delta opioid receptor (DOPR) signaling in the striatum and the desensitization is mediated by the indirect actions of cocaine on dopamine D1 receptors (D1R). In addition, DOPR and D1R co-exist in some rat striatal ... |
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Dopamine D1 receptor signaling system regulates ryanodine receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons.
J. Neurochem. 118(5) , 773-83, (2011) Regulatory mechanisms of ryanodine receptor (RyR) expression are not well known, although methamphetamine (METH) has been reported to up-regulate RyRs in mouse brain. This study investigate regulatory mechanisms of RyR expression by dopaminergic system using ... |
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Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction.
Psychopharmacology 202(4) , 731-43, (2009) Previous studies have suggested that chronic food restriction (FR) increases sensitivity of a neural substrate for drug reward. The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor... |
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Blockade of neurokinin-3 receptors modulates dopamine-mediated behavioral hyperactivity.
Neuropharmacology 57(3) , 295-301, (2009) Acute activation or blockade of neurokinin-3 (NK-3) receptors has been shown to alter dopamine-mediated function and behaviors, however long-term effects of NK-3 receptor blockade remain largely unknown. The present study investigated whether acute and repeat... |
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Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect.
Bipolar Disord. 11(8) , 885-96, (2009) Lithium, valproate, and carbamazepine decrease stimulated brain cyclic-AMP (cAMP) levels. Adenylyl cyclase (AC), of which there are nine membrane-bound isoforms (AC1-AC9), catalyzes the formation of cAMP. We have recently demonstrated preferential inhibition ... |
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Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine.
Biol. Psychiatry 63(11) , 1066-74, (2008) Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after pr... |
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Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat.
Psychopharmacology 201(4) , 495-506, (2009) Food restriction (FR) enhances learned and unlearned behavioral responses to drugs of abuse and increases D-1 dopamine (DA) receptor-mediated activation of extracellular signal-regulated kinases (ERK) 1/2 MAP kinase in nucleus accumbens (NAc). While a role ha... |
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D1/D2-dopamine receptor agonist dihydrexidine stimulates inspiratory motor output and depresses medullary expiratory neurons.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 296(6) , R1829-36, (2009) It is now accepted that dopamine plays an important neuromodulatory role in the central nervous control of respiration. D1, D2, and D4 subtypes of the receptor seem to be important players, but the assignment of various respiratory tasks to specific subtypes ... |