乳糖酸
乳糖酸结构式
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常用名 | 乳糖酸 | 英文名 | Lactobionic acid |
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| CAS号 | 96-82-2 | 分子量 | 358.296 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 864.7±65.0 °C at 760 mmHg | |
| 分子式 | C12H22O12 | 熔点 | 113-118 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 319.1±27.8 °C |
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Galactosylated pullulan-curcumin conjugate micelles for site specific anticancer activity to hepatocarcinoma cells.
Colloids Surf. B Biointerfaces 133 , 347-55, (2015) Galactosylated pullulan-curcumin conjugate (LANH2-Pu Ald-Cur SA) is developed for target specific delivery of curcumin to hepatocarcinoma cells by five step synthetic strategy, which includes oxidation of pullulan (Pu Ald), introduction of amino group to the ... |
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Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma.
J. Liposome Res. 22(3) , 224-36, (2012) The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), con... |
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Targeting liver cancer via ASGP receptor using 5-FU-loaded surface-modified PLGA nanoparticles.
J. Microencapsul. 31(5) , 479-87, (2014) Liver cancer is widespread liver malignancy in the world, for an estimated one million deaths annually.In present work, lactobionic acid conjugated PLGA nanoparticles (LDNPs) bearing 5-Fluorouracil (5-FU) were developed for targeted delivery to hepatocellular... |
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Scaffold materials from glycosylated and PEGylated bovine serum albumin.
J. Biomed. Mater. Res. A 103 , 2839-46, (2015) Bovine serum albumin has been PEGylated and glycosylated to create mimetic materials for the extracellular matrix (ECM) with potential tissue engineering applications. Different surfaces for cell adhesion were achieved by crosslinking the initial albumin prod... |
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Galactosylated poly(ethyleneglycol)-lithocholic Acid selectively kills hepatoma cells, while sparing normal liver cells.
Macromol. Biosci. 15 , 777-87, (2015) Delivering drugs selectively to cancer cells but not to nearby normal cells is a major obstacle in drug therapy. In this study, lithocholic acid (LCA), a potent anti-cancer drug, is converted to two forms of poly(ethyleneglycol) (PEG) conjugates, viz., PEG-LC... |
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Enhanced antitumor efficacies of multifunctional nanocomplexes through knocking down the barriers for siRNA delivery.
Biomaterials 44 , 111-21, (2015) Multifunctional nanocomplexes (NCs) consisting of urocanic acid-modified galactosylated trimethyl chitosan (UA-GT) conjugates as polymeric vectors, poly(allylamine hydrochloride)-citraconic anhydride (PAH-Cit) as charge-reversible crosslinkers, and vascular e... |
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Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes.
J. Invest. Dermatol. 130(2) , 500-10, (2010) Neutralization of the normally acidic stratum corneum (SC) has deleterious consequences for permeability barrier homeostasis and SC integrity/cohesion attributable to serine proteases (SPs) activation leading to deactivation/degradation of lipid-processing en... |
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Hydrotropic polymeric mixed micelles based on functional hyperbranched polyglycerol copolymers as hepatoma-targeting drug delivery system.
J. Pharm. Sci. 102(1) , 145-53, (2013) Mixed copolymer nanoparticles (NPs) self-assembled from β-cyclodextrin-grafted hyperbranched polyglycerol (HPG-g-CD) and lactobionic acid (LA)-grafted hyperbranched polyglycerol (HPG-g-LA) were applied as carriers for a hydrophobic antitumor drug, paclitaxel ... |
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Physiological heterogeneity of Pseudomonas taetrolens during lactobionic acid production.
Appl. Microbiol. Biotechnol. 96(6) , 1465-77, (2012) Physiological heterogeneity constitutes a critical parameter in biotechnological systems since both metabolite yield and productivity are often hampered by the presence of undesired physiological cell subpopulations. In the present study, the physiological st... |
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Production of lactobionic acid and sorbitol from lactose/fructose substrate usingGFOR/GLenzymes fromZymomonas mobiliscells: A kinetic study
Enzyme Microb. Technol. 49(2) , 183-91, (2011) In this work, we have investigated the kinetics of the biotechnological production of lactobionic acid ( LBA) and sorbitol by the catalytic action of glucose–fructose oxidoreductase ( GFOR) and glucono-δ-lactonase ( GL) enzymes. The cells of bacterium Zymomon... |