(8S,10S,13S,14S,17S)-17-(2-(4-(2,6-二(吡咯烷-1-基)嘧啶-4-基)哌嗪-1-基)乙酰基)-10,13-二甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[a]菲-3-酮马来酸盐
![(8S,10S,13S,14S,17S)-17-(2-(4-(2,6-二(吡咯烷-1-基)嘧啶-4-基)哌嗪-1-基)乙酰基)-10,13-二甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[a]菲-3-酮马来酸盐结构式](https://image.chemsrc.com/caspic/283/153190-29-5.png)
(8S,10S,13S,14S,17S)-17-(2-(4-(2,6-二(吡咯烷-1-基)嘧啶-4-基)哌嗪-1-基)乙酰基)-10,13-二甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[a]菲-3-酮马来酸盐结构式
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常用名 | (8S,10S,13S,14S,17S)-17-(2-(4-(2,6-二(吡咯烷-1-基)嘧啶-4-基)哌嗪-1-基)乙酰基)-10,13-二甲基-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[a]菲-3-酮马来酸盐 | 英文名 | U 74389G maleate |
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| CAS号 | 153190-29-5 | 分子量 | 726.904 | |
| 密度 | N/A | 沸点 | 811.6ºC at 760 mmHg | |
| 分子式 | C41H54N6O6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 444.6ºC |
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Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.
Neuropharmacology 99 , 422-31, (2015) Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concen... |
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Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.
Hepatology 34(5) , 990-9, (2001) Portal hypertensive (PHT) gastropathy is a frequent, serious complication of liver cirrhosis. PHT gastric mucosa has numerous abnormalities such as reduced mucosal potential differences, reduced surface oxygenation, and increased susceptibility to injury caus... |
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Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.
Circulation 92 , 238, (1995) Transition metals such as copper are known to initiate free radical formation and lipid peroxidation. Recent reports suggest that intracellular reactive oxygen intermediates can induce the transcription of a number of important genes. The present study examin... |
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Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells.
J. Am. Soc. Nephrol. 6 , 1300, (1995) F2-isoprostanes are the newly identified reactive oxygen species-catalyzed peroxidation products of arachidonate. The infusion of these prostaglandin F2-like prostanaoids into the rat kidney induces profound parallel reductions in RBF and GFR, suggesting that... |
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21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers.
Free Radic. Biol. Med. 19 , 349, (1995) Selected 21-aminosteroids (U74500A, U74006F, and U74389G) and a 2-(aminomethyl)chromans (U78517F) were tested for their efficacy in preventing arachidonate-induced lipid peroxidation and permeability alterations in brain microvessel endothelial cells (BMECs).... |
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Effectiveness of sildenafil and U-74389G in a rat model of colitis.
J. Surg. Res. 193(2) , 667-74, (2015) Crohn disease is still incurable. Compounds with anti-inflammatory and/or antioxidative effects are tested in various preclinical models of the disease. Our aim was to investigate the effects of sildenafil and lazaroid U-74389G in an experimental rat model of... |
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The effect of U-74389G on pancreas ischemia-reperfusion injury in a swine model.
J. Surg. Res. 187(2) , 450-7, (2014) Oxidative stress is a crucial factor in the pathophysiology of acute pancreatitis and its systemic complications. Lazaroids are a novel class of antioxidants that potently protect pancreatic acinar cells against oxidant attack. The aim of our study was to eva... |
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Modulation of crucial adenosinetriphosphatase activities due to U-74389G administration in a porcine model of intracerebral hemorrhage.
Metab. Brain Dis. 28(3) , 439-46, (2013) Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPase... |