α-苯基环戊基乙酸
α-苯基环戊基乙酸结构式
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常用名 | α-苯基环戊基乙酸 | 英文名 | α-Cyclopentylphenylacetic Acid |
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| CAS号 | 3900-93-4 | 分子量 | 204.26500 | |
| 密度 | 1.141g/cm3 | 沸点 | 337.2ºC at 760mmHg | |
| 分子式 | C13H16O2 | 熔点 | 98-100 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 234.2ºC |
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Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Bioorg. Med. Chem. 22(17) , 4968-97, (2014) TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido m... |
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Soft drugs. 3. A new class of anticholinergic agents.
J. Med. Chem. 23(5) , 474-80, (1980) A new class of antimuscarinic drugs was designed and synthesized. The compounds are "soft" quaternary ammonium esters in which there is only one carbon atom separating the ester oxygen and the quaternary head. The compounds are potent anticholinergics when de... |
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Studies on the metabolic clearance of ciclotropium to alpha-phenylciclopentylacetic acid using a new enantiospecific metabolite assay.
Arzneimittelforschung 42(11) , 1354-8, (1992) Ester hydrolysis represents an important biotransformation pathway for various parasympatholytic agents. Cleavage of the ciclotropium ester bond results in the formation of alpha-phenylciclopentylacetic acid (PCA). The relevance of this metabolic route for ci... |
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Design, pharmacokinetic, and pharmacodynamic evaluation of soft anticholinergics based on tropyl alpha-phenylcyclopentylacetate.
Pharmazie 57(2) , 115-21, (2002) Four new soft anticholinergic agents based on tropyl alpha-phenylcyclopentylacetate, 15a, 15b, 18a, and 18b, were designed and synthesized. Receptor binding studies on the cloned human muscarinic receptors indicated that the new soft anticholinergic agents po... |
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664. Chemical constitution and sex-hormonal activity: the synthesis of of some 1-cyclopentyl-and 1-cyclohexyl-1: 2-diarylethylenes. Hey DH and Musgrave OC.
J. Chem. Soc. , 3156-64, (1949)
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