新穿心莲内酯
新穿心莲内酯结构式
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常用名 | 新穿心莲内酯 | 英文名 | Neoandrographolide |
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| CAS号 | 27215-14-1 | 分子量 | 480.591 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 668.1±55.0 °C at 760 mmHg | |
| 分子式 | C26H40O8 | 熔点 | 167-168ºC | |
| MSDS | 中文版 美版 | 闪点 | 220.1±25.0 °C |
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Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata.
Biochem. Pharmacol. 46(1) , 182-5, (1993) The diterpenes andrographolide (I), andrographiside (II) and neoandrographolide (III) isolated from Andrographis paniculata were investigated for their protective effects on hepatotoxicity induced in mice by carbon tetrachloride or tert-butylhydroperoxide (tB... |
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Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression.
Int. Immunopharmacol. 10(11) , 1361-73, (2010) In inflammation, the responses to noxious stimuli are controlled by the highly modulated interactions between various immune cells and chemical mediators. The purpose of this study is to evaluate and compare the anti-inflammatory effect of diterpenoids isolat... |
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Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.
J. Pharm. Biomed. Anal. 70 , 87-93, (2012) A quantitative proton nuclear magnetic resonance technique (qHNMR) has been successfully introduced to quantify andrographolide, dehydroandrographolide, deoxyandrographolide and neoandrographolide in Andrographis paniculata, a commonly used important traditio... |
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Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage.
Mol. Cell Biochem. 298(1-2) , 49-57, (2007) Activated macrophages express inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), produce excessive amounts of nitric oxide (NO) and prostaglandin E(2) (PGE(2)), which play key roles in the processes of inflammation. Andrographis ... |
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Microbial transformation of neoandrographolide by Aspergillus niger (AS 3.739).
J. Asian Nat. Prod. Res. 9(3-5) , 463-9, (2007) The biotransformation of neoandrographolide (1) was investigated by using Aspergillus niger (AS 3.739). Five products were obtained and identified as 8(17),13-ent-labdadien-16,15-olid-19-oic acid (2), 19-hydroxy-8(17),13-ent-labdadien-16,15-olide (3), 18-hydr... |
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Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.
Biochem. J. 338 ( Pt 1) , 107-13, (1999) Studies were performed to investigate the prohormone/proprotein convertase (PC)-inhibitory properties of chemical constituents of the medicinally active plant Andrographis paniculata (AP; from the family Acanthaceae), also known as 'King of Bitters'. Among th... |
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[Studies on diterpenoids from Andrographis paniculata].
Zhongguo Zhong Yao Za Zhi 31(19) , 1594-7, (2006) To study the diterpenoids in the 85% ethanol extract of the aerial parts of Andrographis paniculata.Fourteen diterpenoids from the 85% EtOH extract were isolated by the silica gel, Sephadex LH-20, ODS column chromatography and HPLC, and their structures were ... |
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Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
Med. Res. Rev. 28(5) , 746-72, (2008) Medicinal plants have been traditionally used for treating liver diseases since centuries. Several leads from plant sources have been found as potential hepatoprotective agents with diverse chemical structures. Although, a big list of hepatoprotective phytomo... |
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Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata.
Biol. Pharm. Bull. 25(9) , 1169-74, (2002) In this study, we investigated the in vitro and ex vivo suppressive effects of Andrographis paniculata on nitric oxide (NO) production in mouse peritoneal macrophages elicited by bacillus Calmette-Guéin (BCG) and stimulated by lipopolysaccharide (LPS). Incuba... |
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Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography.
J. Chromatogr. A. 984(1) , 147-51, (2003) The bioactive diterpenes andrographolide and neoandrographolide from the leaves of Andrographis paniculata NEES (Acanthaceae) were successfully separated by counter-current chromatography. A single 280-min separation yielded 189 mg of 99.9% andrographolide an... |