FM19G11
FM19G11结构式
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常用名 | FM19G11 | 英文名 | FM19G11 |
|---|---|---|---|---|
| CAS号 | 329932-55-0 | 分子量 | 463.39600 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C23H17N3O8 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression.
Biochim. Biophys. Acta 1847 , 1254-66, (2015) Abnormal accumulation of oncometabolite fumarate and succinate is associated with inhibition of mitochondrial function and carcinogenesis. By competing with α-ketoglutarate, oncometabolites also activate hypoxia inducible factors (HIFs), which makes oncometab... |
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Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
J. Biol. Chem. 291 , 3268-79, (2016) B cell malignancies comprise a diverse group of cancers that proliferate in lymph nodes, bone marrow, and peripheral blood. SIRT3 (sirtuin 3) is the major deacetylase within the mitochondrial matrix that promotes aerobic metabolism and controls reactive oxyge... |
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Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans.
Am. J. Physiol. Gastrointest. Liver Physiol. 307(7) , G673-88, (2014) Solute carrier (SLC) transporters mediate the uptake of biologically active compounds in the intestine. Reduced oxygenation (hypoxia) is an important factor influencing intestinal homeostasis. The aim of this study was to investigate the pathophysiological co... |
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Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1/2α independent manner.
PLoS ONE 8 , e58662, (2013) Although both glucose deprivation and hypoxia have been reported to promote cascades of biological alterations that lead to induction of inflammatory mediators, we hypothesized that glucose deprivation and hypoxia might show neutral, synergistic or antagonist... |