古伦宾
古伦宾结构式
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常用名 | 古伦宾 | 英文名 | Columbin |
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| CAS号 | 546-97-4 | 分子量 | 358.385 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 565.9±50.0 °C at 760 mmHg | |
| 分子式 | C20H22O6 | 熔点 | 190-191ºC | |
| MSDS | 美版 | 闪点 | 296.0±30.1 °C |
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In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-κB translocation.
Eur. J. Pharmacol. 678(1-3) , 61-70, (2012) Columbin, a diterpenoid furanolactone, was isolated purely for the first time from the plant species Tinspora bakis. The anti-inflammatory effects of columbin were studied in vitro, in silico and in vivo. The effect of columbin on nitric oxide was examined on... |
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A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis.
Cancer Lett. 183(2) , 131-9, (2002) The modifying effect of dietary administration of a diterpenoid furanolactone columbin isolated from the crude drug Calumbae Radix (the root of Jateorhiza columba MIERS, Menispermacea) on azoxymethane (AOM)-induced was investigated in male F344 rats. Animals ... |
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Inhibition of Naja nigricolis venom acidic phospholipase A2 catalysed hydrolysis of ghost red blood cells by columbin.
J. Enzyme Inhib. Med. Chem. 17(1) , 55-9, (2002) The inhibitory effects of a naturally occurring diterpenoid furanolactone, columbin, on partially purified acidic phospholipase A2 (PLA2) from Naja nigricolis was investigated. Columbin inhibited the N. nigricolis PLA2 in a dose related pattern with an IC50 v... |
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Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.
Biol. Pharm. Bull. 18(4) , 634-6, (1995) In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethan... |
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Columbin inhibits cholesterol uptake in bloodstream forms of Trypanosoma brucei-A possible trypanocidal mechanism.
J. Enzyme Inhib. Med. Chem. 20(4) , 365-8, (2005) The diterpenoid furanolactone (columbin) from Aristolochia albida inhibited growth of culture forms of Trypanosoma brucei. In vitro analysis of the compound at 5-250 microg/ml showed complete lysis of the parasites within 10-20 minutes post incubation. At 50 ... |
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Quantitative LC/MS/MS method and pharmacokinetic studies of columbin, an anti-inflammation furanoditerpen isolated from Radix Tinosporae.
Biomed. Chromatogr. 21(6) , 642-8, (2007) Columbin is an important component isolated from Radix Tinosporae. It has been demonstrated to possess many pharmacological activities, including anti-inflammation, antitumor and inhibition of enzyme activity in vivo. The purpose of the present study was to e... |
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Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers.
Acta Crystallogr. C 45 ( Pt 2) , 300-3, (1989) (1S,4R,5R,8S,10R,12S)-4-Hydroxy-15,16-epoxycleroda-2,12(16),14- trieno-17,12: 18,1-biscarbolactone, C20H22O6, Mr = 358.2, m.p. = 453-454 K, orthorhombic, P2(1)2(1)2(1), a = 7.3869 (6), b = 11.986 (1), c = 19.896 (2) A, V = 1761.65 A3, Z = 4, Dx = 1.351, Dm(by... |