1,2-二苯基-3-甲基-4-(甲胺基)-2-丁基丙酸酯
1,2-二苯基-3-甲基-4-(甲胺基)-2-丁基丙酸酯结构式
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常用名 | 1,2-二苯基-3-甲基-4-(甲胺基)-2-丁基丙酸酯 | 英文名 | Nor Propoxyphene Maleate Salt |
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| CAS号 | 38910-73-5 | 分子量 | 441.51700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C25H31NO6 | 熔点 | 144-147°C | |
| MSDS | 美版 | 闪点 | N/A |
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Urine drug testing of chronic pain patients. V. Prevalence of propoxyphene following its withdrawal from the United States market.
J. Anal. Toxicol. 37(1) , 1-4, (2013) Propoxyphene is an opioid analgesic that was surrounded by controversy concerning its safety and efficacy during its lifespan in the US market. Propoxyphene was withdrawn in November of 2010 from the US market and is still being detected one year post-withdra... |
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Enhancement of propoxyphene bioavailability by ethanol. Relation to psychomotor and cognitive function in healthy volunteers.
Eur. J. Clin. Pharmacol. 41(2) , 147-52, (1991) The interaction between a single oral dose of 130 mg propoxyphene and 0.5 g/kg body weight ethanol was investigated in 12 healthy male volunteers by 9 objective performance tests, 8 visual analogue self-rating scales and the measurement of plasma propoxyphene... |
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Propoxyphene and norpropoxyphene quantitation in the same solid-phase extraction using Toxi-Lab Spec VC MP3 system.
J. Anal. Toxicol. 18(4) , 217-9, (1994) We have found that in using the Toxi-Lab Spec VC MP3 column we were able to easily identify and quantitate both propoxyphene and the major metabolite, norpropoxyphene, in a single extraction using urine as a matrix. Samples were screened using the Syva EMIT d... |
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Gas chromatographic quantitation of dextropropoxyphene and norpropoxyphene in urine after solid-phase extraction.
J. Anal. Toxicol. 20(7) , 547-54, (1996) A gas chromatographic technique with flame ionization detection, which is based on a solid-phase extraction (SPE) procedure using mixed-mode SPE columns, for the simultaneous quantitation of dextropropoxyphene and norpropoxyphene in urine is presented. Urine ... |
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Determination of dextropropoxyphene and nordextropropoxyphene in urine by liquid chromatography-electrospray ionization mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 794(1) , 57-65, (2003) Dextropropoxyphene and nordextropropoxyphene were extracted from urine samples with mixed mode solid-phase extraction cartridges. After elution and evaporation to dryness, the eluate was dissolved in mobile phase and each sample was injected in a LC-ESI-MS sy... |
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Evaluation of the online immunoassay for propoxyphene: comparison to EMIT II and GC-MS.
J. Anal. Toxicol. 20(7) , 537-40, (1996) A study was conducted to compare the clinical sensitivity of the OnLine and EMIT II assays for propoxyphene (PPX) use in human urine. A total of 5138 random clinical samples were evaluated by both OnLine and EMIT II. Samples that were positive for each immuno... |
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Retrospective diagnosis of an adverse drug reaction in a breastfed neonate: liquid chromatography-tandem mass spectrometry quantification of dextropropoxyphene and norpropoxyphene in newborn and maternal hair.
J. Anal. Toxicol. 32(9) , 787-9, (2008) Dextropropoxyphene (DP) and norpropoxyphene (NP) are commonly used in the treatment of postpartum pain. The drug is widely prescribed in Europe and Canada and has been recently approved for use in the U.S. Its safety during breastfeeding, however, has not bee... |
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Evaluation of the Triage PPY on-site testing device for the detection of dextropropoxyphene in urine.
J. Anal. Toxicol. 28(6) , 485-8, (2004) A new point-of-care colloidal metal immunoassay urine drugs-of-abuse testing device, the BIOSITE TRIAGE Plus Propoxyphene (TPP), was evaluated for the rapid detection of dextropropoxyphene (PPY) and/or its primary metabolite, norpropoxyphene (NP), in urine at... |
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Unstable propoxyphene metabolite excreted in human urine is detected by liquid chromatography-tandem mass spectrometry.
J. Anal. Toxicol. 33(7) , 379-83, (2009) A dilute and shoot method for measuring norpropoxyphene in human urine using liquid chromatography-tandem mass spectrometry distinguishes two different metabolites of propoxyphene, norpropoxyphene (m/z 326) and a dehydrated rearrangement product (m/z 308). Th... |
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Serum propoxyphene concentrations in a cohort of opiate addicts on long-term propoxyphene maintenance therapy. Evidence for drug tolerance in humans.
J. Anal. Toxicol. 12(1) , 25-9, (1988) Propoxyphene, norpropoxyphene, and cyclic dinorpropoxyphene concentrations in the sera of eight opiate addicts were measured by gas chromatography. The addicts were enrolled in a propoxyphene maintenance program and had received 800-1600 mg of propoxyphene na... |