DL-Α-甲基天冬氨酸
DL-Α-甲基天冬氨酸结构式
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常用名 | DL-Α-甲基天冬氨酸 | 英文名 | 2-amino-2-methylsuccinic acid |
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| CAS号 | 2792-66-7 | 分子量 | 147.12900 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C5H9NO4 | 熔点 | 232-234ºC | |
| MSDS | 美版 | 闪点 | N/A |
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Binding of C5-dicarboxylic substrate to aspartate aminotransferase: implications for the conformational change at the transaldimination step.
Biochemistry 44(23) , 8218-29, (2005) The mechanism for the reaction of aspartate aminotransferase with the C4 substrate, l-aspartate, has been well established. The binding of the C4 substrate induces conformational change in the enzyme from the open to the closed form, and the entire reaction p... |
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Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle.
Nitric Oxide 17 , 115-121, (2007) Nitric oxide (NO) is an important vasorelaxant produced along with L-citrulline from L-arginine in a reaction catalyzed by endothelial nitric oxide synthase (eNOS). Previous studies suggested that the recycling of L-citrulline to L-arginine is essential for N... |
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Crystal structures of Escherichia coli aspartate aminotransferase in two conformations. Comparison of an unliganded open and two liganded closed forms.
J. Mol. Biol. 239(2) , 285-305, (1994) Three crystal structures of wild type E. coli aspartate aminotransferase (E.C.2.6.1.1) in space group P2(1) have been determined at resolution limits between 2.6 and 2.35 A. The unliganded enzyme and its complexes with the substrate analogues maleate and 2-me... |
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Receptor sensitivity in bacterial chemotaxis.
Proc. Natl. Acad. Sci. U. S. A. 99(1) , 123-7, (2002) Chemoreceptors in Escherichia coli are coupled to the flagella by a labile phosphorylated intermediate, CheY approximately P. Its activity can be inferred from the rotational bias of flagellar motors, but motor response is stochastic and limited to a narrow p... |
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Role of the L-citrulline/L-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma.
Eur. J. Pharmacol. 546(1-3) , 171-6, (2006) Nitric oxide synthase (NOS) converts L-arginine into nitric oxide (NO) and L-citrulline. In NO-producing cells, L-citrulline can be recycled to L-arginine in a two-step reaction involving argininosuccinate synthase (ASS) and -lyase (ASL). In guinea pig trache... |
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Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production.
J. Biol. Chem. 284(30) , 20022-33, (2009) Bj-BPP-10c is a bioactive proline-rich decapeptide, part of the C-type natriuretic peptide precursor, expressed in the brain and in the venom gland of Bothrops jararaca. We recently showed that Bj-BPP-10c displays a strong, sustained anti-hypertensive effect ... |
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Frequency-dependent Escherichia coli chemotaxis behavior.
Phys. Rev. Lett. 108(12) , 128101, (2012) We study Escherichia coli chemotaxis behavior in environments with spatially and temporally varying attractant sources by developing a unique microfluidic system. Our measurements reveal a frequency-dependent chemotaxis behavior. At low frequency, the E. coli... |
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Adaptation kinetics in bacterial chemotaxis.
J. Bacteriol. 154(1) , 312-23, (1983) Cells of Escherichia coli, tethered to glass by a single flagellum, were subjected to constant flow of a medium containing the attractant alpha-methyl-DL-aspartate. The concentration of this chemical was varied with a programmable mixing apparatus over a rang... |
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Refinement and comparisons of the crystal structures of pig cytosolic aspartate aminotransferase and its complex with 2-methylaspartate.
J. Biol. Chem. 272(28) , 17293-302, (1997) Two high resolution crystal structures of cytosolic aspartate aminotransferase from pig heart provide additional insights into the stereochemical mechanism for ligand-induced conformational changes in this enzyme. Structures of the homodimeric native structur... |
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Locomotor network maturation is transiently delayed in the MAOA-deficient mouse.
J. Neurophysiol. 83(4) , 2468-70, (2000) In vivo and in vitro experiments were performed in control (C3H) and monoamine oxidase A (MAOA)-deficient (Tg8) neonatal mice to determine whether MAOA deficiency affected spinal locomotor network maturation. Comparing the swimming behaviors at birth in C3H m... |