TAS-301
TAS-301结构式
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常用名 | TAS-301 | 英文名 | TAS 301 |
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| CAS号 | 193620-69-8 | 分子量 | 357.402 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 573.2±50.0 °C at 760 mmHg | |
| 分子式 | C23H19NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 300.5±30.1 °C |
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TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
J. Pharmacol. Exp. Ther. 285 , 1280-1286, (1998) The purpose of this study was to determine the efficacy and the possible mechanism of action of a recently synthesized drug, TAS-301 [3-bis (4-methoxyphenyl)methylene-2-indolinone], on intimal formation in comparison with those of tranilast, the clinical effi... |
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TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factor.
Jpn. J. Pharmacol. 84(3) , 252-8, (2000) The purpose of this study was to determine the effect of a recently synthesized drug, TAS-301 [3-bis(4-methoxyphenyl)methylene-2-indolinone], on vascular smooth muscle cell (VSMC) proliferation and the intracellular signal transduction pathways involved in VS... |
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Tas-301, a new synthetic inhibitor of neointimal thickening after balloon injury, inhibits calcium-dependent signal transduction and cytoskeletal reorganization.
Pharmacology 63 , 17-27, (2001) We previously demonstrated that a recently synthesized drug, TAS-301 [3-bis(4-methoxyphenyl)methylene-2-indolinone], inhibited neointimal thickening after single-balloon injury to the rat common carotid artery by inhibiting both the migration and proliferatio... |