Xenin
Xenin结构式
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常用名 | Xenin | 英文名 | Xenin 25 acetate salt |
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| CAS号 | 144092-28-4 | 分子量 | 2971.57000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C139H224N38O32S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Xenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons.
Am. J. Physiol. Gastrointest. Liver Physiol. 303(12) , G1347-55, (2012) Xenin-25 (Xen) is a 25 amino acid neurotensin-related peptide reportedly produced with glucose-dependent insulinotropic polypeptide (GIP) by a subset of K cells in the proximal gut. We previously showed exogenously administered Xen, with GIP but not alone, in... |
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Xenin plasma concentrations during modified sham feeding and during meals of different composition demonstrated by radioimmunoassay and chromatography.
Regul. Pept. 111(1-3) , 153-9, (2003) Xenin is a 25 amino acid peptide produced by specific endocrine cells of the duodenal mucosa. Xenin has multiple biological actions in the gastrointestinal tract. It modulates intestinal motility, affects exocrine pancreatic secretion, and gastric secretion o... |
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Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety.
J. Endocrinol. 207(1) , 87-93, (2010) Recently, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) have received much attention regarding possible roles in aetiology and treatment of type 2 diabetes. However, peptides co-secreted from the same enteroendocrine ce... |
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Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas.
Regul. Pept. 115(1) , 25-9, (2003) Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family identified in gastric mucosa as well as in a number of tissues, including the pancreas of various mammals. In healthy subjects, plasma xenin immunoreactivity increases after meals. Infusion o... |
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Metabolism and potency of xenin and of its reduced hexapseudopeptide psi fragment in the dog.
Life Sci. 74(6) , 697-707, (2003) Xenin is a 25 amino acid peptide hormone, secreted into the circulation by specific endocrine cells in the duodenal mucosa. Plasma concentrations are elevated after sham feeding and feeding. In the present study the metabolism of xenin and of a C-terminal fra... |
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Interaction of xenin with the neurotensin receptor of guinea pig enteral smooth muscles.
Peptides 23(3) , 523-9, (2002) Xenin, a 25 aminoacid peptide, interacts with the neurotensin receptor subtype 1 of intestinal muscles of the guinea pig. Replacement of the C-terminal Lys -Arg peptide bond in xenin 6 by a reduced pseudo-peptide bond augmented binding affinity to isolated je... |
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Mechanisms of xenin-induced anorectic response in chicks (Gallus gallus).
Gen. Comp. Endocrinol. 157(1) , 58-62, (2008) We recently reported that the 25 amino acid peptide xenin caused reduced feed intake when centrally injected in chicks. The present study was designed to explore possible mechanisms of the xenin-induced anorexigenic response in chicks. In Experiments 1 and 2,... |
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Characterisation of the biological activity of xenin-25 degradation fragment peptides.
J. Endocrinol. 221(2) , 193-200, (2014) Xenin-25, a peptide co-secreted with the incretin hormone glucose-dependent insulinotropic polypeptide (GIP), possesses promising therapeutic actions for obesity-diabetes. However, native xenin-25 is rapidly degraded by serum enzymes to yield the truncated me... |
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Xenin delays gastric emptying rate and activates the brainstem in mice.
Neurosci. Lett. 481(1) , 59-63, (2010) Xenin, a 25-amino acid gastrointestinal peptide, inhibits feeding by acting through the central nervous system. Gastrointestinal hormones reduce food intake partly by activating the brainstem and inhibiting gastric emptying. Therefore, we hypothesized that xe... |
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Evidence for non-neurotensin receptor-mediated effects of xenin (1-25)--focus on intestinal microcirculation.
Regul. Pept. 107(1-3) , 23-7, (2002) Xenin (1-25) has been detected in various locations in mammalians. It has structural similarities with neurotensin and its intestinal effects are claimed to be mediated by neurotensin receptors. It has been shown to influence gastrointestinal motility. The ef... |