氨甲叶酸杂质C
氨甲叶酸杂质C结构式
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常用名 | 氨甲叶酸杂质C | 英文名 | 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid |
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| CAS号 | 2410-93-7 | 分子量 | 455.42400 | |
| 密度 | 1.61g/cm3 | 沸点 | N/A | |
| 分子式 | C20H21N7O6 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
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The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.
Lancet 2(8242) , 337-40, (1981) It is suggested that in man the methyl folate trap is a normal physiological response to impending methyl group deficiency resulting from a very low supply of methionine. This decreases cellular S-adenosyl-methionine (SAM), which puts at risk important methyl... |
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Enhancement of recovery from psychiatric illness by methylfolate.
Lancet 336(8712) , 392-5, (1990) 41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial ... |
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Differential effects of stimulus termination on excitation and desensitization of folic acid receptors and guanylate cyclase in Dictyostelium discoideum.
Biochim. Biophys. Acta 930(1) , 1-9, (1987) The response of guanylate cyclase to addition of extracellular stimuli is well documented. Here we report for the first time the response of guanylate cyclase to removal of stimuli. Three methods were employed to terminate rapidly a stimulus of folic acid. (1... |
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Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
J. Med. Chem. 29(6) , 1080-7, (1986) Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an investigation of 5-alkyl-5-deaza an... |
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Enhancement of recovery from psychiatric illness by methylfolate.
Br. J. Psychiatry 159 , 271-2, (1991) "41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial... |
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An impurity, N10-methylfolate, associated with methotrexate inhibits folate binding in milk and serum.
Biochem. Pharmacol. 29(22) , 3109-12, (1980)
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Decreased ornithine decarboxylase in the fetal hydantoin syndrome.
Ann. Clin. Lab. Sci. 12(3) , 216-22, (1982) The anticonvulsant diphenylhydantion (DPH) causes embryonic folate antagonism in the animal model of the fetal hydantoin syndrome. Thus, comparisons were made between the metabolic effects of the teratogens DPH and 9-methyl pteroylglutamic acid (9-methyl PGA)... |
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Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes.
Int. J. Vitam. Nutr. Res. 54(2-3) , 195-7, (1984) N10-methylfolate acted as a potent competitive inhibitor of high-affinity [3H] folate binding in human leukocytes, while methotrexate had no effect. Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate. Hence, in... |
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Enhancement of recovery from psychiatric illness by methylfolate.
Lancet 336(8730) , 1579-80, (1990)
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Enhancement of recovery from psychiatric illness by methylfolate.
Br. J. Psychiatry 161 , 126-7, (1992)
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