L-亮氨酰-L-亮氨酰-L-亮氨酸
L-亮氨酰-L-亮氨酰-L-亮氨酸结构式
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常用名 | L-亮氨酰-L-亮氨酰-L-亮氨酸 | 英文名 | H-Leu-Leu-Leu-OH |
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| CAS号 | 10329-75-6 | 分子量 | 357.48800 | |
| 密度 | 1.057g/cm3 | 沸点 | 589.6ºC at 760mmHg | |
| 分子式 | C18H35N3O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 310.4ºC |
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Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].
Proc. Natl. Acad. Sci. U. S. A. 107 , 18143-18148, (2010) Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cel... |
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Trileucine improves aerosol performance and stability of spray-dried powders for inhalation.
J. Pharm. Sci. 97 , 287-302, (2008) For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge because as p... |
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Temozolomide delivery to tumor cells by a multifunctional nano vehicle based on poly(β-L-malic acid).
Pharm. Res. 27 , 2317-2329, (2010) Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus needed to... |
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Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.
Am. J. Physiol. Gastrointest. Liver Physiol. 301 , G69-81, (2011) ATP7A and ATP7B are copper-transporting P-type ATPases that are essential to eukaryotic copper homeostasis and must traffic between intracellular compartments to carry out their functions. Previously, we identified a nine-amino acid sequence (F37-E45) in the ... |
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Investigation of the adsorption mechanism of a peptide in reversed phase liquid chromatography, from pH controlled and uncontrolled solutions.
J. Chromatogr. A. 1216 , 3992-4004, (2009) The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorptio... |
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Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90.
Biochem. J. 333 ( Pt 2) , 407-15, (1998) Heat-shock protein 90 (Hsp 90) has been implicated in both protection against oxidative inactivation and inhibition of the multicatalytic proteinase (MCP, also known as 20 S proteasome). We report here that the protective and inhibitory effects of Hsp 90 depe... |
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Comparative peptide specificity of cell wall, membrane and intracellular peptidases of group N streptococci.
J. Appl. Bacteriol. 58(5) , 449-55, (1985) Solubilized cell walls of group N streptococci contain two electrophoretically distinct peptidases, one of which hydrolysed trileucine only, while the second hydrolysed a wide range of di- and tripeptides. Neither enzyme possessed leucine aminopeptidase or en... |
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Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers.
Biomaterials 34(1) , 217-25, (2013) Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hy... |
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Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain.
J. Biol. Chem. 276(27) , 25114-20, (2001) Interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is an essential binding component for IL-13-mediated ligand binding. Recently, we have demonstrated that this receptor chain also plays an important role in the internalization of IL-13. To study the me... |
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Importance of NF-kappaB in rheumatoid synovial tissues: in situ NF-kappaB expression and in vitro study using cultured synovial cells.
Ann. Rheum. Dis. 60(7) , 678-84, (2001) To examine whether inhibition of NF-kappaB induces apoptosis of human synovial cells stimulated by tumour necrosis factor alpha (TNFalpha), interleukin 1beta (IL1beta), and anti-Fas monoclonal antibody (mAb).The expression of proliferating cell nuclear antige... |