麦角硫因
麦角硫因结构式
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常用名 | 麦角硫因 | 英文名 | L-(+)-Ergothioneine |
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| CAS号 | 497-30-3 | 分子量 | 229.299 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C9H15N3O2S | 熔点 | 275-277ºC (dec.) | |
| MSDS | 美版 | 闪点 | N/A |
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Effect of mushroom diet on pharmacokinetics of gabapentin in healthy Chinese subjects.
Br. J. Clin. Pharmacol. 78(1) , 129-34, (2014) This study evaluated the pharmacokinetics of gabapentin in Chinese subjects who received a diet rich in shiitake mushrooms. Shiitake mushrooms have been shown to contain high amount of ergothioneine. In vitro studies have shown that OCTN1-mediated secretion o... |
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The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.
Eukaryotic Cell 11(10) , 1226-38, (2012) The function of a number of genes in the gliotoxin biosynthetic cluster (gli) in Aspergillus fumigatus remains unknown. Here, we demonstrate that gliK deletion from two strains of A. fumigatus completely abolished gliotoxin biosynthesis. Furthermore, exogenou... |
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Uptake and protective effects of ergothioneine in human endothelial cells.
J. Pharmacol. Exp. Ther. 350(3) , 691-700, (2014) Ergothioneine is a thiourea derivative of histidine found in food, especially mushrooms. Experiments in cell-free systems and chemical assays identified this compound as a powerful antioxidant. Experiments were designed to test the ability of endothelial cell... |
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Biochemistry: Elusive source of sulfur unravelled.
Nature 518(7537) , 45-6, (2015)
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Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A.
Nature 518(7537) , 115-9, (2015) Low-molecular-mass thiols in organisms are well known for their redox-relevant role in protection against various endogenous and exogenous stresses. In eukaryotes and Gram-negative bacteria, the primary thiol is glutathione (GSH), a cysteinyl-containing tripe... |
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Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
Int. J. Med. Mushrooms 17 , 511-20, (2015) In humans, skin pigmentation results from the biochemichal synthesis and accumulation of melanin. We previously revealed that edible winter mushroom Flammulina velutipes extract inhibited melanosis in commercially available edible crustacea. Therefore, the cu... |
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Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses.
Org. Lett. 15(18) , 4854-7, (2013) Ergothioneine (5) and ovothiol (8) are two novel thiol-containing natural products. Their C-S bonds are formed by oxidative coupling reactions catalyzed by EgtB and OvoA enzymes, respectively. In this work, it was discovered that in addition to catalyzing the... |
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Chemical Composition and Medicinal Value of Fruiting Bodies and Submerged Cultured Mycelia of Caterpillar Medicinal Fungus Cordyceps militaris CBS-132098 (Ascomycetes).
Int. J. Med. Mushrooms 17 , 649-59, (2015) In this paper, we report the results of a proximate analysis (i.e., moisture, ash, protein, fat, carbohydrates, and energy); a bioactive compounds analysis (i.e., cordycepin and ergothioneine); fatty and amino acid analysis; and analyses of vitamin content, m... |
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Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms.
Int. J. Med. Mushrooms 15(3) , 315-23, (2013) Mushrooms (including fruiting bodies and mycelia) contain several bioactive components such as lovastatin, γ-aminobutyric acid (GABA), and ergothioneine. This article reports the results of 49 samples, including 9 fruiting bodies, 39 mycelia, and 1 vegetative... |
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Quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry.
J. Mass Spectrom. 48(3) , 406-12, (2013) A sensitive analytical method has been developed and validated for the quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry. A commercially available isotope-labeled L-ergothioneine-d9 is used as... |