替普瑞酮
替普瑞酮结构式
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常用名 | 替普瑞酮 | 英文名 | Teprenone |
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| CAS号 | 6809-52-5 | 分子量 | 330.55 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 442.2±24.0 °C at 760 mmHg | |
| 分子式 | C23H38O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 168.0±9.8 °C |
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Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury.
Mol. Med. Report. 11(3) , 1793-9, (2014) X‑linked inhibitor of apoptosis protein (XIAP) negatively regulates apoptotic pathways at a post‑mitochondrial level. XIAP functions by directly binding and inhibiting activation of specific caspases. Upon apoptotic stimuli, mitochondrial second mitochondria‑... |
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Aldioxa improves delayed gastric emptying and impaired gastric compliance, pathophysiologic mechanisms of functional dyspepsia.
Sci. Rep. 5 , 17519, (2015) Delayed gastric emptying and impaired gastric accommodation (decreased gastric compliance) play important roles in functional dyspepsia (FD). Here we screen for a clinically used drug with an ability to improve delayed gastric emptying in rats. Oral administr... |
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Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS).
BMC Gastroenterol. 12 , 42, (2012) In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms.This was a randomized, open-label, parallel-g... |
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Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.
Am. J. Physiol. Endocrinol. Metab. 300(5) , E894-901, (2011) We evaluated heat shock protein 70 (HSP70) changes in diabetes mellitus (DM) in a nonhuman primate model. To this end, two studies were conducted in DM vervet monkeys. 1) Normal control and streptozotocin-induced DM monkeys (Stz-DM) that were differentiated i... |
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Isoprenoid geranylgeranylacetone inhibits human colon cancer cells through induction of apoptosis and cell cycle arrest.
Anticancer Drugs 21(9) , 850-60, (2010) Geranylgeranylacetone (GGA), an isoprenoid compound, is a widely used antiulcer drug developed in Japan. GGA is structurally similar to plaunotol and geranylgeraniol, another isoprenoid reported to exert strong anticancer effects. In an earlier study, GGA was... |
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Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.
J. Orthop. Sci. 16(6) , 791-8, (2011) Osteoarthritis (OA) is a common disease, afflicting many sufferers with both pain and functional disorders. Various therapies have been attempted for OA, but no fully effective treatment has been established yet. Apoptosis of chondrocytes caused by reactive o... |
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Geranylgeranylacetone, heat shock protein 90/AMP-activated protein kinase/endothelial nitric oxide synthase/nitric oxide pathway, and endothelial function in humans.
Arterioscler. Thromb. Vasc. Biol. 32(1) , 153-60, (2012) Geranylgeranylacetone (GGA) induces expression of heat shock protein 90 (Hsp90), an adaptor molecule for assembly of endothelial nitric oxide synthase (eNOS) phosphorylation complex. The purpose of this study was to determine whether GGA enhances Hsp90 expres... |
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Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.
Br. J. Pharmacol. 162(8) , 1832-42, (2011) The expression of voltage-dependent K(+) channels (K(v) ) 1.5 is regulated by members of the heat shock protein (Hsp) family. We examined whether the heat shock transcription factor 1 (HSF-1) and its inducer geranylgeranylacetone (GGA) could affect the expres... |
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Neuroprotective effects of geranylgeranylacetone in experimental traumatic brain injury.
J. Cereb. Blood Flow Metab. 33(12) , 1897-908, (2013) Geranylgeranylacetone (GGA) is an inducer of heat-shock protein 70 (HSP70) that has been used clinically for many years as an antiulcer treatment. It is centrally active after oral administration and is neuroprotective in experimental brain ischemia/stroke mo... |
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Geranylgeranylacetone protects the heart via caveolae and caveolin-3
Life Sci. 101(1-2) , 43-8, (2014) Aims Geranylgeranylacetone (GGA) is commonly utilized to protect the gastric mucosa in peptic ulcer disease. Recently GGA has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. However, the exact mechanism as to ... |