CGS-9895
CGS-9895结构式
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常用名 | CGS-9895 | 英文名 | CGS-9895 |
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| CAS号 | 77779-50-1 | 分子量 | 291.30400 | |
| 密度 | 1.338g/cm3 | 沸点 | 518.6ºC at 760 mmHg | |
| 分子式 | C17H13N3O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 267.5ºC |
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Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats.
Eur. J. Pharmacol. 263(1-2) , 141-7, (1994) The effects of benzodiazepine receptor ligands with different intrinsic activity profiles were studied on voluntary ethanol consumption in the selectively bred alcohol-preferring AA (Alko, Alcohol) rat line, and compared to those of an opiate antagonist, nalo... |
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Comparison of a new class of pyrrole containing benzodiazepine ligands to the pyrazoloquinolinones CGS 9896, 9895, and 8216.
Med. Chem. Res. 4(5) , 307-14, (1994) Four pyrazoloquninolinone compounds, variations of known high affinity ligands for the GABA A/Benzodiazepine receptors (BDZRs), were synthesized and their affinities for BDZRs in cerebellum and spinal cord measured and compared to the parent compounds, CGS 82... |
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Benzodiazepine-induced hyperphagia: stereospecificity and antagonism by pyrazoloquinolines, CGS 9895 and CGS 9896.
Psychopharmacology 89(4) , 462-6, (1986) Non-deprived male rats were familiarized with a highly palatable diet until baseline consumption in a 30-min daily access period had stabilised. Stereospecificity of the hyperphagic effect of benzodiazepine receptor agonists was demonstrated using two enantio... |
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Differential diazepam-antagonist effects of the benzodiazepine receptor ligand CGS 9895 in rodents.
J. Pharmacol. Exp. Ther. 235(3) , 589-95, (1985) CGS 9895, a pyrazoloquinolone benzodiazepine receptor ligand, was administered alone and concomitantly with diazepam in order to assess its agonist and diazepam-antagonist properties on various behaviors in rodents. In mice, CGS 9895 neither potentiated nor b... |
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Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats.
Eur. J. Pharmacol. 92(1-2) , 155-7, (1983) The diazepam-like agonist and diazepam antagonist properties of the pyrazoloquinoline benzodiazepine receptor ligands CGS8216, CGS9895 and CGS9896 were evaluated in rats trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice, discret... |
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Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.
Physiol. Behav. 41(3) , 241-5, (1987) Five compounds that bind to the benzodiazepine (BZ) receptor, but show different pharmacological characteristics from the classical BZs, are profiled. CGS 8216 is a BZ antagonist/inverse agonist that reverses the effects of diazepam and also acts as a proconv... |
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In vivo determination of efficacy of pyrazoloquinolinones at the benzodiazepine receptor.
Eur. J. Pharmacol. 103(1-2) , 139-43, (1984) The pyrazoloquinolinones CGS 9896, CGS 9895 and CGS 8216 potently displace the benzodiazepines from their CNS binding site in vitro but have been reported to display agonist, partial agonist and antagonist activity respectively in a number of in vivo tests in... |
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Benzodiazepine receptor modulation of [35S]TBPS binding to the chloride channel. Noncompetitive inhibition of classical benzodiazepines and competitive inhibition of the partial agonist, CGS 9895, by CGS 8216.
Neuropharmacology 26(7A) , 775-8, (1987) Benzodiazepine receptor ligands are known to modulate the binding of [35S]TBPS to the chloride channel via an allosteric action. In the cases of diazepam, zopiclone and CGS 9895, the enhanced binding of [35S]TBPS induced by these benzodiazepine agonists was a... |
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Partial agonists acting at benzodiazepine receptors can be differentiated in tests of ingestional behaviour.
Physiol. Behav. 41(3) , 247-55, (1987) Several categories of compounds active at benzodiazepine receptors (BZR) in the brain have been distinguished: agonists, antagonists and the novel category of inverse agonist. In terms of their effects on ingestional responses (e.g., food, saline and water co... |
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Pyrazoloquinoline benzodiazepine receptor ligands: effects on schedule-controlled behavior in dogs.
Pharmacol. Biochem. Behav. 23(2) , 317-23, (1985) The effects of diazepam and the pyrazoloquinoline benzodiazepine receptor ligands CGS8216, CGS9896, and CGS9895 on schedule-controlled responding were studied in dogs. Responding was maintained under a multiple fixed-interval (FI) 5-min fixed-ratio (FR) 30 re... |