N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐
![N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐结构式](https://image.chemsrc.com/caspic/013/220953-69-5.png)
N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐结构式
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常用名 | N-丁基-N-乙基-2,5,6-三甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶基-4-胺盐酸盐 | 英文名 | Antalarmin hydrochloride |
|---|---|---|---|---|
| CAS号 | 220953-69-5 | 分子量 | 415.014 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C24H35ClN4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
Nat. Commun. 6 , 6770, (2015) Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here we show that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IP... |
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CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration.
Neuropsychopharmacology 40(6) , 1549-59, (2015) Alcohol dependence is a complex disorder that initiates with episodes of excessive alcohol drinking known as binge drinking. It has a 50-60% risk contribution from inherited susceptibility genes; however, their exact identity and function are still poorly und... |
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Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1.
Neuropsychopharmacology 40(5) , 1203-15, (2015) During the early postnatal period, environmental influences play a pivotal role in shaping the development of the neocortex, including the prefrontal cortex (PFC) that is crucial for working memory and goal-directed actions. Exposure to stressful experiences ... |
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Loss of cannabinoid receptor CB1 induces preterm birth.
PLoS ONE 3 , e3320, (2008) Preterm birth accounting approximate 10% of pregnancies in women is a tremendous social, clinical and economic burden. However, its underlying causes remain largely unknown. Emerging evidence suggests that endocannabinoid signaling via cannabinoid receptor CB... |
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Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze.
Behav. Brain Res. 271 , 249-57, (2014) Corticotropin-releasing factor (CRF) plays a critical role in the mediation of physiological and behavioral responses to stressors. In the present study, we investigated the role played by the CRF system within the dorsomedial hypothalamus (DMH) in the modula... |
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Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice.
Prog. Neuropsychopharmacol. Biol. Psychiatry 27 , 625-631, (2003) Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This stu... |
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Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
Brain Res. 952 , 188-199, (2002) Molecular studies point to a role for the type 1 corticotropin-releasing factor receptor (CRF(1)) in anxiogenic-like and activating effects of CRF and stress. However, CP-154,526, a selective CRF(1) antagonist, has yielded mixed results in such tests. Few stu... |
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Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys.
Pharmacol. Biochem. Behav. 85 , 744-751, (2006) Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA "stress" axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF(1) receptor antagonist, antalarmin, ... |
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Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome.
Nat. Genet. 44 , 206-11, (2012) Genomic duplications spanning Xq28 are associated with a spectrum of phenotypes, including anxiety and autism. The minimal region shared among affected individuals includes MECP2 and IRAK1, although it is unclear which gene when overexpressed causes anxiety a... |