PD173074
PD173074结构式
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常用名 | PD173074 | 英文名 | PD173074 |
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| CAS号 | 219580-11-7 | 分子量 | 523.670 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C28H41N7O3 | 熔点 | 82-85°C | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nat. Biotechnol. , doi:10.1038/nbt.3297, (2015) During embryonic development, skeletal muscles arise from somites, which derive from the presomitic mesoderm (PSM). Using PSM development as a guide, we establish conditions for the differentiation of monolayer cultures of mouse embryonic stem (ES) cells into... |
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Glypican-5 Increases Susceptibility to Nephrotic Damage in Diabetic Kidney.
Am. J. Pathol. 185 , 1889-98, (2015) Type 2 diabetes mellitus is a leading health issue worldwide. Among cases of diabetes mellitus nephropathy (DN), the major complication of type 2 diabetes mellitus, the nephrotic phenotype is often intractable to clinical intervention and demonstrates the rap... |
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Mesenchymal TGF-β signaling orchestrates dental epithelial stem cell homeostasis through Wnt signaling.
Stem Cells 32(11) , 2939-48, (2014) In mouse, continuous growth of the postnatal incisor is coordinated by two populations of multipotent progenitor cells, the dental papilla mesenchymal cells and dental epithelial stem cells, residing at the proximal end of the incisor, yet the molecular mecha... |
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Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth.
J. Clin. Invest. 124(7) , 3016-31, (2014) Neuroblastoma prognosis is dependent on both the differentiation state and stromal content of the tumor. Neuroblastoma tumor stroma is thought to suppress neuroblast growth via release of soluble differentiating factors. Here, we identified critical growth-li... |
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FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.
Development 134 , 2895-2902, (2007) Pluripotent embryonic stem (ES) cells must select between alternative fates of self-replication and lineage commitment during continuous proliferation. Here, we delineate the role of autocrine production of fibroblast growth factor 4 (Fgf4) and associated act... |
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Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.
PLoS ONE 5 , e11644, (2010) Heparan sulfate (HS) is an important regulator of the assembly and activity of various angiogenic signalling complexes. However, the significance of precisely defined HS structures in regulating cytokine-dependent angiogenic cellular functions and signalling ... |