N-甲酰甘氨酸
N-甲酰甘氨酸结构式
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常用名 | N-甲酰甘氨酸 | 英文名 | N-Formylglycine |
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| CAS号 | 2491-15-8 | 分子量 | 103.07700 | |
| 密度 | 1.307 g/cm3 | 沸点 | 450.2ºC at 760 mmHg | |
| 分子式 | C3H5NO3 | 熔点 | 149-151 °C | |
| MSDS | 中文版 美版 | 闪点 | 226.1ºC |
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New aldehyde tag sequences identified by screening formylglycine generating enzymes in vitro and in vivo.
J. Am. Chem. Soc. 130(37) , 12240-1, (2008) Formylglycine generating enzyme (FGE) performs a critical posttranslational modification of type I sulfatases, converting cysteine within the motif CxPxR to the aldehyde-bearing residue formylglycine (FGly). This concise motif can be installed within heterolo... |
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The ribosome as an entropy trap.
Proc. Natl. Acad. Sci. U. S. A. 101(21) , 7897-901, (2004) To determine the effectiveness of the ribosome as a catalyst, we compared the rate of uncatalyzed peptide bond formation, by the reaction of the ethylene glycol ester of N-formylglycine with Tris(hydroxymethyl)aminomethane, with the rate of peptidyl transfer ... |
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Function and structure of a prokaryotic formylglycine-generating enzyme.
J. Biol. Chem. 283(29) , 20117-25, (2008) Type I sulfatases require an unusual co- or post-translational modification for their activity in hydrolyzing sulfate esters. In eukaryotic sulfatases, an active site cysteine residue is oxidized to the aldehyde-containing C(alpha)-formylglycine residue by th... |
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Electron transfer in amino acid.nucleic acid base complexes: EPR, ENDOR, and DFT study of X-irradiated N-formylglycine.cytosine complex crystals.
J. Phys. Chem. A 110(28) , 8653-62, (2006) Single crystals of the 1:1 complex of the nucleic acid base cytosine and the dipeptide N-formylglycine (C.NFG) have been irradiated at 10 and 273 K to doses of about 70 kGy and studied at temperatures between 10 and 293 K using 24 GHz (K-band) and 9.5 GHz (X-... |
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A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum.
J. Mol. Biol. 384(1) , 120-36, (2008) The alkaline phosphatase superfamily comprises a large number of hydrolytic metalloenzymes such as phosphatases and sulfatases. We have characterised a new member of this superfamily, a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium legumino... |
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Inhibition of succinic semialdehyde dehydrogenase by N-formylglycine.
J. Enzym. Inhib. 13(5) , 369-76, (1998) N-formylglycine was developed as a dead-end inhibitor of the succinic semialdehyde dehydrogenase reaction. At 4 mM, it inhibited Aspergillus niger succinic semialdehyde dehydrogenase by 40%. N-formylglycine is a reversible, complete inhibitor; the inhibition ... |
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The non-catalytic N-terminal extension of formylglycine-generating enzyme is required for its biological activity and retention in the endoplasmic reticulum.
J. Biol. Chem. 283(17) , 11556-64, (2008) Formylglycine-generating enzyme (FGE) catalyzes the oxidation of a specific cysteine residue in nascent sulfatase polypeptides to formylglycine (FGly). This FGly is part of the active site of all sulfatases and is required for their catalytic activity. Here w... |
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Proprotein convertases process and thereby inactivate formylglycine-generating enzyme.
J. Biol. Chem. 288(8) , 5828-39, (2013) Formylglycine-generating enzyme (FGE) post-translationally converts a specific cysteine in newly synthesized sulfatases to formylglycine (FGly). FGly is the key catalytic residue of the sulfatase family, comprising 17 nonredundant enzymes in human that play e... |
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Amino acids derivatives synthesis from nitrogen, carbon and water by electric discharges.
Orig. Life 11(4) , 317-20, (1981) Electric discharges between a pair of carbon electrodes were continued for 50 days in a vessel of 5 liters in volume which initially contained nitrogen at a pressure of 15 cm Hg and 200 ml of water. The pressure in the vessel was gradually increased to 60 cm ... |
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Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals.
FEBS J. 275(6) , 1118-30, (2008) Formylglycine-generating enzyme (FGE) catalyzes in newly synthesized sulfatases the oxidation of a specific cysteine residue to formylglycine, which is the catalytic residue required for sulfate ester hydrolysis. This post-translational modification occurs in... |