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TPBM

TPBM结构式
TPBM结构式
品牌特惠专场
常用名 TPBM 英文名 TPBM
CAS号 6466-43-9 分子量 316.37800
密度 1.373g/cm3 沸点 569.6ºC at 760mmHg
分子式 C15H16N4O2S 熔点 N/A
MSDS 美版 闪点 298.3ºC

A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.

J. Biol. Chem. 285(53) , 41863-73, (2010)

The mechanisms responsible for 17β-estradiol (E(2))-stimulated breast cancer growth and development of resistance to tamoxifen and other estrogen receptor α (ERα) antagonists are not fully understood. We describe a new tool for dissecting ERα action in breast...

A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.

J. Biol. Chem. 283 , 12819-12830, (2008)

Estrogen receptor alpha (ERalpha) plays an important role in several human cancers. Most current ERalpha antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. Instead of the traditional approach of targeting e...