B-苄氧羰基-亮氨酸-亮氨酸-正缬氨酸
B-苄氧羰基-亮氨酸-亮氨酸-正缬氨酸结构式
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常用名 | B-苄氧羰基-亮氨酸-亮氨酸-正缬氨酸 | 英文名 | MG-115 |
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| CAS号 | 133407-86-0 | 分子量 | 461.59 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 678.8±55.0 °C at 760 mmHg | |
| 分子式 | C25H39N3O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 364.3±31.5 °C |
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Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials.
Malaria Journal 14 , 200, (2015) The ubiquitin proteasome system (UPS) is one of the main proteolytical pathways in eukaryotic cells and plays an essential role in key cellular processes such as cell cycle, stress response, signal transduction, and transcriptional regulation. Many components... |
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3,4,5-tricaffeoylquinic acid attenuates proteasome inhibition-mediated programmed cell death in differentiated PC12 cells.
Neurochem. Res. 39(8) , 1416-25, (2014) The dysfunction of the proteasome system is suggested to be implicated in neuronal degeneration. Caffeoylquinic acid derivatives have demonstrated anti-oxidant and anti-inflammatory effects. However, the effect of 3,4,5-tricaffeoylquinic acid on the neuronal ... |
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HEMERA Couples the Proteolysis and Transcriptional Activity of PHYTOCHROME INTERACTING FACTORs in Arabidopsis Photomorphogenesis.
Plant Cell 27 , 1409-27, (2015) Phytochromes (phys) are red and far-red photoreceptors that control plant development and growth by promoting the proteolysis of a family of antagonistically acting basic helix-loop-helix transcription factors, the PHYTOCHROME-INTERACTING FACTORs (PIFs). We h... |
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New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes.
Pharm. Res. 32 , 1957-74, (2015) Release of siRNA from nanoscale polyplexes is a crucial yet little investigated process, important during all stages of therapeutic research. Here we develop new methods to characterize polyplex stability early on in the development of new materials.We used d... |
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Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.
Oncogene 34 , 3391-401, (2015) MLL (myeloid/lymphoid or mixed-lineage leukemia) rearrangements are frequent in therapy-related and childhood acute leukemia, and are associated with poor prognosis. The majority of the rearrangements fall within a 7.3-kb MLL breakpoint cluster region (MLLbcr... |
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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants.
PLoS ONE 9(6) , e95032, (2014) Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing agen... |
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Degradation of polyomavirus JC T-antigen by stress involves the LIP isoform of C/EBP.
Cell Cycle 14 , 2075-9, (2015) Endoplasmic reticulum (ER) stress is caused by the accumulation of misfolded or unfolded proteins in the lumen of the endoplasmic reticulum. CCAAT/enhancer binding proteins are one of the cellular proteins whose expression is upregulated during ER stress. Pre... |
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Detailed analysis of cell cycle kinetics upon proteasome inhibition.
Cytometry 28 , 243-252, (1997) We have studied specific effects of proteasome inhibition on cell cycle progression. To this end, the protease inhibitors MG115, calpain inhibitor I, and calpain inhibitor II, which display differential inhibitory effects on proteasomes, were used. Cell kinet... |
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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.
Cell 78 , 761-771, (1994) Reagents that inhibit the ubiquitin-proteasome proteolytic pathway in cells have not been available. Peptide aldehydes that inhibit major peptidase activities of the 20S and 26S proteasomes are shown to reduce the degradation of protein and ubiquitinated prot... |
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Proteasome inhibitors: valuable new tools for cell biologists.
Trends Cell Biol. 8 , 397-403, (1998) Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen pres... |