8-(4-氯苯硫基)鸟苷3',5'-环一磷酸钠盐
8-(4-氯苯硫基)鸟苷3',5'-环一磷酸钠盐结构式
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常用名 | 8-(4-氯苯硫基)鸟苷3',5'-环一磷酸钠盐 | 英文名 | 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT |
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| CAS号 | 51239-26-0 | 分子量 | 509.79300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C16H14ClN5NaO7PS | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.
Neuropharmacology 99 , 422-31, (2015) Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concen... |
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Adenosine modulates light responses of rat retinal ganglion cell photoreceptors througha cAMP-mediated pathway.
J. Physiol. 592(Pt 19) , 4201-20, (2014) Adenosine is an established neuromodulator in the mammalian retina, with A1 adenosine receptors being especially prevalent in the innermost ganglion cell layer. Activation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cycl... |
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Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
Am. J. Physiol. Renal Physiol. 306(12) , F1442-50, (2014) The emerging role of the transient receptor potential cation channel isotype 6 (TRPC6) as a central contributor to various pathological processes affecting podocytes has generated interest in the development of therapeutics to modulate its function. Recent in... |
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Soluble guanylate cyclase as a novel treatment target for osteoporosis.
Endocrinology 155(12) , 4720-30, (2014) Osteoporosis is a major health problem leading to fractures that cause substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, creating a need for novel bone-anabolic agents. We previously showed that the nitric oxide/c... |
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Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells.
Oncol. Lett. 10 , 502-508, (2015) Enhanced motility of cancer cells is a critical step in promoting tumor metastasis, which remains the major cause of gastric cancer-associated mortality. The small GTPase Rac1 is a key signaling component in the regulation of cell migration. Previous studies ... |
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Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine monophosphate-dependent protein kinase.
Oncol. Lett. 10 , 479-484, (2015) Nitric oxide (NO) may activate soluble guanylyl cyclase (sGC), resulting in the increase of intracellular cyclic guanosine monophosphate (cGMP), a key molecule in the activation of type II cGMP-dependent protein kinase (PKG II). In our previous study, the mem... |
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Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.
Biochem. Biophys. Res. Commun. 449(3) , 357-63, (2014) In platelets, nitric oxide (NO) activates cGMP/PKG signalling, whereas prostaglandins and adenosine signal through cAMP/PKA. Cyclic nucleotide signalling has been considered to play an inhibitory role in platelets. However, an early stimulatory effect of NO a... |
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Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue.
Nat. Commun. 6 , 7235, (2015) Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase... |
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Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for 'BNP resistance'.
Eur. J. Heart Fail. 17 , 475-83, (2015) The release of the B-type natriuretic peptide (BNP) is increased in heart failure (HF), a condition associated with oxidative stress. BNP is known to exert anti-inflammatory effects including suppression of neutrophil superoxide (O2(-)) release. However, BNP-... |
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Interaction of cyclic GMP and cyclic AMP during neutrophil migration: involvement of phosphodiesterase type III.
Biochem. Pharmacol. 56 , 1061-1063, (1998) In previous experiments, it was shown that migration of electropermeabilized human neutrophils induced by a combination of cGMP and cAMP markedly lower relative to that induced by cGMP or cAMP alone. However, when cGMP was replaced with 8-(para-chlorophenylth... |