3-硝基荧蒽
3-硝基荧蒽结构式
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常用名 | 3-硝基荧蒽 | 英文名 | 3-Nitrofluoranthene |
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| CAS号 | 892-21-7 | 分子量 | 247.24800 | |
| 密度 | 1.422g/cm3 | 沸点 | 445.5ºC at 760 mmHg | |
| 分子式 | C16H9NO2 | 熔点 | 157-159ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 223.5ºC |
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Erythrocyte enzymes catalyze 1-nitropyrene and 3-nitrofluoranthene nitroreduction.
Toxicology 108(1-2) , 101-8, (1996) Nitroarenes are environmental contaminants produced during incomplete combustion processes. Nitroreduction, the most important pathway of nitroarene toxification, occurs mainly in the liver and intestine. In the present study, we show that human red cells may... |
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Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.
Eur. J. Med. Chem. 45 , 4562-9, (2010) A quantitative structure-activity relationship (QSAR) study of twenty flavonoid derivatives with antimutagenic activity against 3-nitrofluoranthene (3-NFA) was performed by Partial Least Squares (PLS), using Ordered Predictors Selection (OPS) algorithm for va... |
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The use of silver solid amalgam electrodes for voltammetric and amperometric determination of nitrated polyaromatic compounds used as markers of incomplete combustion.
ScientificWorldJournal 2012 , 231986, (2012) Genotoxic nitrated polycyclic aromatic hydrocarbons (NPAHs) are formed during incomplete combustion processes by reaction of polycyclic aromatic hydrocarbons (PAHs) with atmospheric nitrogen oxides. 1-Nitropyrene, 2-nitrofluorene, and 3-nitrofluoranthene as t... |
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Metabolic activation of the genotoxic environmental contaminants 2- and 3-nitrofluoranthene in variants of Salmonella typhimurium TA98.
Mutagenesis 10(6) , 497-504, (1995) The mutagenic environmental pollutants 2-nitrofluoranthene (2-NFA) and 3-nitrofluoranthene (3-NFA), labelled with 3H and 14C respectively, were incubated with Salmonella typhimurium strain TA98, its nitroreductase-deficient variant TA98NR and its O-acetytrans... |
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Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats.
Carcinogenesis 12(6) , 1003-7, (1991) 3,9- and 3,7-Dinitrofluoranthene (3,9- and 3,7-DNF), 3-nitrofluoranthene (3-NF) and benzo[a]pyrene (B[a]P) were tested for pulmonary carcinogenicity by intrapulmonary implantation of the compounds into rat lung. These chemicals were given in various doses as ... |
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Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.
Mutagenesis 24(6) , 481-93, (2009) We previously reported that 1-nitropyrene (1-NP) and 3-nitrofluoranthene (3-NF) elicited apoptotic cell death as well as non-apoptotic programmed cell deaths (PCDs) with paraptotic and necroptotic characteristics, respectively. In the present study, we have f... |
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The kinetics of 1-nitropyrene and 3-nitrofluoranthene metabolism using bovine liver xanthine oxidase.
Cancer Lett. 54(1-2) , 37-42, (1990) The cytosolic molybdoflavoprotein xanthine oxidase has been shown to catalyze the reduction of exocyclic nitro groups to the corresponding nitroso, hydroxylamino and amino derivatives for a wide variety of xenobiotics including the nitrated polycyclic aromati... |
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Characterization of oxidative and reductive metabolism in vitro of nitrofluoranthenes by rat liver enzymes.
Carcinogenesis 11(2) , 213-8, (1990) Nitrofluoranthenes (NFs) are mutagenic and carcinogenic environmental pollutants found in incomplete combustion products and urban air particulate. We have studied both oxidative and reductive metabolism in vitro of different NF isomers mediated by subcellula... |
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Fungal metabolism of nitrofluoranthenes.
J. Toxicol. Environ. Health A 53(2) , 153-74, (1998) Metabolism of 2-nitrofluoranthene (2-NFA), one of the most abundant and genotoxic environmental pollutants in air, and of a mixture of 2-nitrofluoranthene and 3-nitrofluoranthene (3-NFA) was studied using (1) the fungus Cunninghamella elegans ATCC 36112 and (... |
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Metabolism of nitrofluoranthenes by rat lung subcellular fractions.
Carcinogenesis 14(6) , 1161-6, (1993) The nitrofluoranthene (NF) family of compounds includes the potent pulmonary carcinogen 3,9-dinitrofluoranthene (3,9-DNF) and the weak carcinogen 3-nitrofluoranthene (3-NF). Although the specific molecular mechanisms involved in this difference in sensitivity... |