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N-叔丁基羟胺盐酸盐

N-叔丁基羟胺盐酸盐结构式
N-叔丁基羟胺盐酸盐结构式
品牌特惠专场
常用名 N-叔丁基羟胺盐酸盐 英文名 n-(tert-butyl)hydroxylamine hydrochloride
CAS号 57497-39-9 分子量 125.597
密度 0.883g/cm3 沸点 120.9ºC at 760mmHg
分子式 C4H12ClNO 熔点 183-185 °C(lit.)
MSDS 中文版 美版 闪点 43.6ºC

N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro.

FASEB J. 15(12) , 2196-204, (2001)

N-t-butyl hydroxylamine (NtBHA) delays senescence-dependent changes in human lung fibroblasts (IMR90) (Atamna et al., J. Biol. Chem. 275, 6741-6748). The current study examines the effect of NtBHA on mitochondria in old and young rats and human primary fibrob...

Developmental differences in the immortalization of lung fibroblasts by telomerase.

Aging Cell 2(5) , 235-43, (2003)

The role of ambient (21%) and physiological oxygen (2-5%) in the immortalization of fetal vs. adult human lung fibroblasts was examined. Growth in low oxygen and antioxidants extended the lifespan of both fetal and adult strains. As the ectopic expression of ...

A New Three-Component Cascade Reaction to Yield 3-Spirocyclopropanatedß-Lactams. Zanobini A, et al.

European J. Org. Chem. 2006(5) , 1251-55, (2006)

Synthesis of alpha-ketoamides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides.

Angew. Chem. Int. Ed. Engl. 47(5) , 947-50, (2008)

Spin trapping by use of N-tert-butylhydroxylamine. Involvement of Fenton reactions.

Free Radic. Res. Commun. 14(5-6) , 395-407, (1991)

Spin trapping of short-lived R. radicals is done by use of N-tert-butylhydroxylamine (1) and H2O2. The hydroxylamine is oxidized to the radical t-BuN(O)H (2) which is converted into the spin trap 2-methyl-2-nitrosopropane (3). Simultaneously, hydroxyl radical...

Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells.

Biochim. Biophys. Acta 1803(10) , 1142-53, (2010)

Reactivation of telomerase in endothelial cells (ECs) may be an effective approach to the treatment of vascular disorders associated with telomere attrition and EC senescence. However, overexpression of human telomerase reverse transcriptase (hTERT) does not ...

Iron accumulation during cellular senescence.

Ann. N. Y. Acad. Sci. 1019 , 365-7, (2004)

Iron accumulates as a function of age and is associated with the pathology of numerous age-related diseases. These changes may be caused by altered iron homeostasis at the cellular level, yet this is poorly understood. Therefore, changes in iron content in pr...

Iron accumulation during cellular senescence in human fibroblasts in vitro.

Antioxid. Redox Signal. 5(5) , 507-16, (2003)

Iron accumulates as a function of age in several tissues in vivo and is associated with the pathology of numerous age-related diseases. The molecular basis of this change may be due to a loss of iron homeostasis at the cellular level. Therefore, changes in ir...

N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration.

FASEB J. 21(14) , 4077-86, (2007)

Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in the elderly in developed countries. AMD patients have elevated levels of iron within the retinal pigment epithelia (RPE), which may lead to oxidative damage to mitochon...

On the anti-aging activities of aminoguanidine and N-t-butylhydroxylamine.

Mech. Ageing Dev. 122(2) , 169-71, (2001)