2-氨基-3-(4-氟-1H-吲哚-3-基)丙酸
2-氨基-3-(4-氟-1H-吲哚-3-基)丙酸结构式
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常用名 | 2-氨基-3-(4-氟-1H-吲哚-3-基)丙酸 | 英文名 | 4-Fluorotryptophan |
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| CAS号 | 25631-05-4 | 分子量 | 222.216 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 450.7±45.0 °C at 760 mmHg | |
| 分子式 | C11H11FN2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 226.4±28.7 °C |
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Fluorine-19 nuclear magnetic resonance spectroscopic study of fluorophenylalanine- and fluorotryptophan-labeled avian egg white lysozymes.
Biochemistry 33(17) , 5238-45, (1994) We report the 470-MHz (11.7 T) 19F solution nuclear magnetic resonance (NMR) spectra of 2-, 3-, and 4-fluorophenylalanine incorporated into the egg white lysozymes (EC 3.2.1.17) of chicken, pheasant, and duck, as well as spectra of 4-fluorotryptophan incorpor... |
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Atomic mutations at the single tryptophan residue of human recombinant annexin V: effects on structure, stability, and activity.
Biochemistry 38(33) , 10649-59, (1999) The single tryptophan residue (Trp187) of human recombinant annexin V, containing 320 residues and 5328 atoms, was replaced with three different isosteric analogues where hydrogen atoms at positions 4, 5, and 6 in the indole ring were exchanged with fluorine.... |
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Incorporation of tryptophan analogues into staphylococcal nuclease, its V66W mutant, and Delta 137-149 fragment: spectroscopic studies.
Biochemistry 37(25) , 8938-46, (1998) We have biosynthetically incorporated several tryptophan analogues into three forms of Staphylococcal nuclease to investigate the spectroscopic characteristics of these "intrinsic" probes and their effect on the structure of the proteins. The set of tryptopha... |
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Phosphorescence and optically detected magnetic resonance characterization of the environments of tryptophan analogues in staphylococcal nuclease, its V66W mutant, and Delta 137-149 fragment.
Biochemistry 37(25) , 8954-64, (1998) Phosphorescence and optically detected magnetic resonance (ODMR) measurements are reported on the triplet states of the tryptophan analogues, 7-azatryptophan (7AW), 5-hydroxytryptophan (5HW), and 4-, 5-, and 6-fluorotryptophan (4FW, 5FW, 6FW), when incorporat... |
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Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells.
ChemMedChem 3 , 1449, (2008) Nonproteinogenic amino acids that either occur naturally or are synthesized chemically are becoming important tools in modern drug discovery. In this context, fluorinated amino acids have great potential in the development of novel pharmaceuticals and drugs. ... |
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Tryptophanyl-tRNA synthetase from Bacillus subtilis. Characterization and role of hydrophobicity in substrate recognition.
J. Biol. Chem. 264(8) , 4304-11, (1989) The tryptophanyl-tRNA synthetase from Bacillus subtilis was purified to homogeneity and characterized. It has an alpha 2 subunit structure and a molecular weight of 77,000. Tryptophanyl-tRNA synthetase does not catalyze any significant proofreading. It activa... |
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Mechanistic studies on CymD: a tryptophan reverse N-prenyltransferase.
Biochemistry 51(39) , 7733-9, (2012) The prenyltransferase CymD catalyzes the reverse N-prenylation of tryptophan using dimethylallyl diphosphate (DMAPP) in the biosynthesis of the cyclic peptides cyclomarin and cyclomarazine. The mechanism is of interest because a non-nucleophilic indole nitrog... |
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Distortion of the catalytic domain of tissue-type plasminogen activator by plasminogen activator inhibitor-1 coincides with the formation of stable serpin-proteinase complexes.
J. Biol. Chem. 278(48) , 48197-203, (2003) Plasminogen activator inhibitor-1 (PAI-1) is a typical member of the serpin family that kinetically traps its target proteinase as a covalent complex by distortion of the proteinase domain. Incorporation of the fluorescently silent 4-fluorotryptophan analog i... |
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tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding.
EMBO J. 19 , 5599-5610, (2000) The 2.2 A crystal structure of a ternary complex formed by yeast arginyl-tRNA synthetase and its cognate tRNA(Arg) in the presence of the L-arginine substrate highlights new atomic features used for specific substrate recognition. This first example of an act... |
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Assignment and analysis of fluorine nuclear magnetic resonance spectra of 4-fluorotryptophan myoglobins and hemoglobins.
Biochemistry 36 , 3590-3599, (1997) We have obtained the 470 MHz 19F NMR spectra of wild type [4-F]Trp-labeled myoglobins (MbCO, MbO2, deoxyMb, metMb, and MbCN) and hemoglobins (HbCO, HbO2, and deoxyHb), as well as those of several mutants (W7F Mb, betaW15F Hb, betaW37S Hb, and betaY130F Hb, al... |