AMPHIREGULIN(AR), HUMAN, RECOMBINANT
AMPHIREGULIN(AR), HUMAN, RECOMBINANT结构式
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常用名 | AMPHIREGULIN(AR), HUMAN, RECOMBINANT | 英文名 | AMPHIREGULIN(AR), HUMAN, RECOMBINANT |
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| CAS号 | 117147-70-3 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat.
Am. J. Physiol. Lung Cell. Mol. Physiol. 304(12) , L853-62, (2013) Allergen challenges induce airway hyperresponsiveness (AHR) and increased airway smooth muscle (ASM) mass in the sensitized rat. Whether the remodeled ASM changes its phenotype is uncertain. We examined, in sensitized Brown Norway rats, the effects of multipl... |
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Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging.
Eur. J. Mass Spectrom. (Chichester, Eng.) 19(1) , 17-28, (2013) The study of the expression and the tissue distribution of the tyrosine kinase drug-target epidermal growth factor receptor (EGFR) is of interest in oncology as a marker of potential efficacy of treatment. It has been reported, however, that the response rate... |
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Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Proc. Natl. Acad. Sci. U. S. A. 110(24) , 9776-81, (2013) Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease... |
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Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
J. Pharmacol. Exp. Ther. 348(2) , 236-45, (2014) Rheumatoid arthritis (RA) is a chronic autoimmune disease with high morbidity and mortality. Within the inflammatory milieu, resident fibroblast-like synoviocytes (FLS) in the synovial tissue undergo hyperplasia, which leads to joint destruction. Epidemiologi... |
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[Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue].
Harefuah 152(6) , 326-9, 369, (2013) Progress has been made in the treatment of metastatic colorectal cancer with the development of biologic agents such as Cetuximab and Panitumumab. These monoclonal antibodies are directed against EGFR and influence cell division, attachment, angiogenesis, mig... |
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Kinetic and molecular docking studies of loganin and 7-O-galloyl-D-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase.
Arch. Pharm. Res. 38 , 1090-8, (2015) Aldose reductase (AR) is a key enzyme in the polyol pathway that is strongly implicated in the pathogenesis of diabetic complications. AR inhibitors have been proposed as therapeutic agents for diabetic complications through suppression of sorbitol formation ... |
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cAMP-dependent regulation of ovulatory response genes is amplified by IGF1 due to synergistic effects on Akt phosphorylation and NF-κB transcription factors.
Reproduction 144(5) , 595-602, (2012) Granulosa cells play a crucial role as mediator of the LH-dependent ovulatory response. The intraovarian factor IGF1 is produced by ovarian somatic cells of healthy follicles during the ovulatory response. The objective of this study was to identify mechanism... |
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Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle.
Biol. Reprod. 91(1) , 9, (2014) Luteinizing hormone (LH) regulation of the epidermal growth factor (EGF) network is critical for oocyte maturation and the ovulatory process. Recent studies have indicated that C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (... |
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High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model.
Am. J. Physiol. Gastrointest. Liver Physiol. 305(1) , G35-46, (2013) Decreased bone mineral density (BMD) represents an extraintestinal complication of inflammatory bowel disease (IBD). Vitamin D₃ has been considered a viable adjunctive therapy in IBD. However, vitamin D₃ plays a pleiotropic role in bone modeling and regulates... |
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Different Growth Patterns of Canine Prostatic Carcinoma Suggests Different Models of Tumor-Initiating Cells.
Vet. Pathol. 52 , 1027-33, (2015) Controversies remain regarding the cell type from which human prostate cancer originates, and many attempts have been made to identify the cellular origin of canine prostate cancer but without definitive proof. This study aims to evaluate the expression of lu... |